Document 0528
 DOCN  M9590528
 TI    Virus-induced increases in airway mast cells in brown Norway rats are
       associated with enhanced pulmonary viral replication and persisting
       lymphocytic infiltration.
 DT    9509
 AU    Sorden SD; Castleman WL; Department of Comparative and Experimental
       Pathology, College of; Veterinary Medicine, University of Florida,
       Gainesville, USA.
 SO    Exp Lung Res. 1995 Mar-Apr;21(2):197-213. Unique Identifier : AIDSLINE
       MED/95292898
 AB    Brown Norway (BN) rats are more susceptible than Fischer 344 (F344) rats
       to parainfluenza virus-induced lung injury and to bronchiolar mast cell
       increases that are associated with persistent airway
       hyperresponsiveness. In this study, pulmonary viral replication as well
       as immune, inflammatory, and airway mast cell responses to Sendai virus
       infection were compared between neonatal BN and F344 rats. BN rats
       supported prolonged viral replication, and viral titers in BN rats were
       5-fold higher (p < .05) than in F344 rats at 7 days after inoculation.
       F344 rats had 18-fold higher (p < .06) numbers of lymphocytes in
       bronchoalveolar lavage fluid at 7 days after inoculation than did BN
       rats. Persisting bronchiolar aggregates of lymphocytes, plasma cells,
       and macrophages were more common, and increases in bronchiolar mast
       cells were greater in BN rats than in F344 rats. No strain differences
       were detected in bronchiolar intramural infiltrates of CD4 + or CD8 +
       cells. The greater susceptibility of BN rats to virus-induced increases
       in bronchiolar mast cells and airway responsiveness may be the result of
       their less efficient viral clearance mechanisms and more persistent
       bronchiole-centered inflammatory response.
 DE    Animal  Antibodies, Viral/ANALYSIS  Bronchi/PATHOLOGY  Bronchoalveolar
       Lavage Fluid/CYTOLOGY  Cell Count  Cell Movement  CD4-CD8 Ratio
       Eosinophils/PATHOLOGY  Lung/IMMUNOLOGY/*PATHOLOGY/*VIROLOGY
       Lymphocytes/*PHYSIOLOGY  Mast Cells/*PATHOLOGY  Parainfluenza Virus Type
       1/*PHYSIOLOGY  Pneumonia, Viral/PATHOLOGY/VIROLOGY  Rats  Rats, Inbred
       F344  Support, U.S. Gov't, P.H.S.  *Virus Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).