Document 0529
 DOCN  M9590529
 TI    Prospects for the use of antioxidant therapies.
 DT    9509
 AU    Maxwell SR; Department of Medicine, Queen Elizabeth Hospital,
       Birmingham,; England.
 SO    Drugs. 1995 Mar;49(3):345-61. Unique Identifier : AIDSLINE MED/95292865
 AB    Free radical oxidative stress has been implicated in the pathogenesis of
       a variety of human diseases. Natural antioxidant defences have been
       found to be defective in many of the same diseases. This has led to
       suggestions that oxidative damage and therefore disease progression may
       be retarded by supplementing natural antioxidant defences. Potential
       antioxidant therapy includes natural antioxidant enzymes and vitamins or
       synthetic agents with antioxidant activity. Diseases where antioxidant
       therapy may be beneficial include diabetes mellitus, reperfusion injury,
       inflammatory diseases and the prevention of chronic processes such as
       atherosclerosis and carcinogenesis. Further well controlled prospective
       clinical trials of antioxidants are required to establish the efficacy
       and tolerability of antioxidant therapy in the treatment of human
       diseases.
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY/PREVENTION &  CONTROL
       Antioxidants/ADMINISTRATION & DOSAGE/PHARMACOLOGY/*THERAPEUTIC  USE
       Atherosclerosis/DRUG THERAPY/PREVENTION & CONTROL  Central Nervous
       System Diseases/DRUG THERAPY/PREVENTION & CONTROL  Diabetes
       Mellitus/DRUG THERAPY/PREVENTION & CONTROL  Enzymes/ADMINISTRATION &
       DOSAGE/PHARMACOLOGY/THERAPEUTIC USE  Exercise  Free Radical
       Scavengers/ADMINISTRATION & DOSAGE/PHARMACOLOGY/  THERAPEUTIC USE  Free
       Radicals  Graft Rejection/PREVENTION & CONTROL  Human  Hypertension/DRUG
       THERAPY/PREVENTION & CONTROL  Inflammation/DRUG THERAPY/PREVENTION &
       CONTROL  Neoplasms/DRUG THERAPY/PREVENTION & CONTROL  Reperfusion
       Injury/DRUG THERAPY/PREVENTION & CONTROL  JOURNAL ARTICLE  REVIEW
       REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).