Document 0538
 DOCN  M9590538
 TI    Contact allergy to gold sodium thiosulfate.
 DT    9509
 AU    McKenna KE; Dolan O; Walsh MY; Burrows D; Department of Dermatology,
       Royal Victoria Hospitals Trust,; Belfast, Northern Ireland, UK.
 SO    Contact Dermatitis. 1995 Mar;32(3):143-6. Unique Identifier : AIDSLINE
       MED/95292526
 AB    278 consecutive patients with suspected contact dermatitis were patch
       tested with the European standard series and gold sodium thiosulfate
       (0.5% pet.): 13 patients (4.6%) had a positive allergic response to gold
       sodium thiosulfate (GST). All of these patients were female, with a mean
       age of 37 years. The most frequent site of eczema in these patients was
       the head and neck (62%). A seborrhoeic distribution of eczema was
       common. 46% had involvement of the limbs, 15% had a perianal or
       perivulval rash. The mean duration of eczema in this group of patients
       was 15.8 months. 54% of patients allergic to gold were also allergic to
       nickel. Biopsy of positive patch test reactions to GST were consistent
       with allergic contact dermatitis.
 DE    Adult  Anus Diseases/ETIOLOGY  CD4-Positive T-Lymphocytes/PATHOLOGY
       CD8-Positive T-Lymphocytes/PATHOLOGY  Dermatitis, Allergic
       Contact/*ETIOLOGY/IMMUNOLOGY/PATHOLOGY  Eczema/ETIOLOGY  Female  Gold
       Alloys/ADVERSE EFFECTS  Gold Sodium Thiosulfate/*ADVERSE EFFECTS  Human
       HLA-DP Antigens/ANALYSIS  HLA-DQ Antigens/ANALYSIS  HLA-DR
       Antigens/ANALYSIS  Langerhans Cells/PATHOLOGY  Middle Age
       Nickel/ADVERSE EFFECTS  Patch Tests  T-Lymphocytes/PATHOLOGY  Vulvar
       Diseases/ETIOLOGY  JOURNAL ARTICLE

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