Document 0541
 DOCN  M9590541
 TI    HIV-specific lymphoproliferative responses in asymptomatic HIV-infected
       individuals.
 DT    9509
 AU    Pontesilli O; Carlesimo M; Varani AR; Ferrara R; Guerra EC; Bernardi ML;
       Ricci G; Mazzone AM; D'Offizi G; Aiuti F; Department of Clinical
       Medicine, University of Rome La Sapienza,; Italy.
 SO    Clin Exp Immunol. 1995 Jun;100(3):419-24. Unique Identifier : AIDSLINE
       MED/95292388
 AB    In vitro lymphoproliferative responses to HIV-1 recombinant antigens
       (gp160, p24, and Rev protein) were studied in 83 patients with
       asymptomatic HIV-1 infection (CDC groups II and III) and circulating CD4
       lymphocyte numbers > 400/mm3. Significant response to at least one of
       the three antigens was detected in 52.4% of the subjects, but the
       responses were weak, and concordance of the response to the three
       antigens was rare, the frequency of individuals responding to each
       antigen not exceeding 22.4%. Increasing frequencies of response were
       observed when recall antigens (tetanus toxoid and Candida albicans
       glycomannoprotein) (65.5%) and anti-CD3 MoAb (76.6%) were used as
       stimuli. Although a significant association between lymphocyte response
       to p24, but not gp160, and steadiness of CD4 lymphocyte numbers before
       the assay was observed, no predictive value for lack of CD4 cell
       decrease was confirmed for either antigen, and fluctuation of the
       responses to HIV antigens was seen during subsequent follow up. The
       panel of T cell assays used could be regarded as appropriate for
       monitoring both HIV-specific responses and T lymphocyte function during
       immunotherapy with soluble HIV antigens.
 DE    Adolescence  Adult  Antigens, CD4/METABOLISM  Candida
       albicans/IMMUNOLOGY  CD4 Lymphocyte Count  Female  Gene Products,
       env/METABOLISM  Human  HIV Antigens/*IMMUNOLOGY  HIV
       Infections/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY  Immunologic Memory
       *Lymphocyte Transformation  Male  Membrane Glycoproteins/IMMUNOLOGY
       Middle Age  Mitogens  Protein Precursors/METABOLISM  Recombinant
       Proteins  Support, Non-U.S. Gov't  Tetanus Toxoid/IMMUNOLOGY  JOURNAL
       ARTICLE

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