Document 0547
 DOCN  M9590547
 TI    Structures of DNA and RNA polymerases and their interactions with
       nucleic acid substrates.
 DT    9509
 AU    Arnold E; Ding J; Hughes SH; Hostomsky Z; Center for Advanced
       Biotechnology and Medicine and Rutgers; University Chemistry Department,
       Piscataway, NJ 08854-5638, USA.
 SO    Curr Opin Struct Biol. 1995 Feb;5(1):27-38. Unique Identifier : AIDSLINE
       MED/95292059
 AB    DNA and RNA polymerases are enzymes that are primarily responsible for
       copying genetic material in all living systems. The four polymerases
       whose structures have been determined by X-ray crystallographic methods
       have significant similarities at the polymerase active site that are
       indicative of common requirements for polynucleotide synthesis.
       Structural studies of complexes of the Klenow fragment of Escherichia
       coli DNA polymerase I, HIV type 1 reverse transcriptase, and rat DNA
       polymerase beta with DNA are leading to generalized models for
       catalysis.
 DE    Animal  DNA Polymerase I/CHEMISTRY/METABOLISM  DNA
       Polymerases/*CHEMISTRY/*METABOLISM  Human  Nucleic
       Acids/*CHEMISTRY/*METABOLISM  *Protein Conformation  Rats  Reverse
       Transcriptase/CHEMISTRY/METABOLISM  RNA
       Polymerases/*CHEMISTRY/*METABOLISM  Support, U.S. Gov't, P.H.S.  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).