Document 0552
 DOCN  M9590552
 TI    Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its
       structure-activity correlation with related coumarins, and synergistic
       effects with anti-AIDS nucleosides.
 DT    9509
 AU    Lee TT; Kashiwada Y; Huang L; Snider J; Cosentino M; Lee KH; Natural
       Products Laboratory, School of Pharmacy, University of; North Carolina,
       Chapel Hill 27599, USA.
 SO    Bioorg Med Chem. 1994 Oct;2(10):1051-6. Unique Identifier : AIDSLINE
       MED/95291686
 AB    Suksdorfin (1), which is isolated from the fruit of Lomatium suksdorfii,
       was found to be able to inhibit HIV-1 replication in the T cell line,
       H9, with an average EC50 value of 2.6 +/- 2.1 microM. In addition,
       suksdorfin was also suppressive during acute HIV-1 infections of
       peripheral blood mononuclear cells, monocyte/macrophages and the
       promonocytic cell line, U937. Combinations of 1 and the anti-HIV
       nucleosides ddI and ddC demonstrated statistical synergy in inhibiting
       HIV-1 replication (ddC > ddI). However, the viral inhibition mediated by
       combining 1 with AZT was not statistically synergistic. Furthermore, the
       presence of suksdorfin did not antagonize the suppression mediated by
       the three nucleoside reverse transcriptase inhibitors. Comparison of the
       structure and activity of 1 with those of ten related compounds
       indicated that the dihydroseselin type of pyranocoumarin possessing a
       4'-isovaleryl group is important to suksdorfin's enhanced anti-HIV
       activity.
 DE    Antiviral Agents/*CHEMISTRY/PHARMACOLOGY  Cell Line
       Coumarins/*CHEMISTRY/PHARMACOLOGY  Drug Synergism  Enzyme-Linked
       Immunosorbent Assay  HIV/*DRUG EFFECTS/GROWTH & DEVELOPMENT  HIV Core
       Protein p24/ANALYSIS/IMMUNOLOGY  HIV Infections/DRUG THERAPY/VIROLOGY
       Molecular Structure  Nucleosides/*PHARMACOLOGY  Plants,
       Medicinal/*CHEMISTRY  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes/VIROLOGY  Virus Replication/DRUG EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).