Document 0555 DOCN M9590555 TI HIV retrotransposon activity and the immunopathogenesis of AIDS. DT 9509 AU Johnson EJ; Sizemore RC; Gottlieb AA; Dept of Microbiology and Immunology, Tulane University School of; Medicine, New Orleans, LA 70112-2699, USA. SO Trends Microbiol. 1995 Mar;3(3):115-7. Unique Identifier : AIDSLINE MED/95291653 AB This article presents the new hypothesis that HIV retrotransposon insertional mutagenesis induces genomic effects that bring about immune dysfunction through disruption, deletion or rearrangement of the genome of the host. This activity may be augmented by the action of most, if not all, the cofactors of HIV-induced disease. DE Acquired Immunodeficiency Syndrome/*ETIOLOGY/GENETICS/*IMMUNOLOGY/ VIROLOGY Genome, Human Human HIV/*GENETICS Models, Genetic Mutagenesis, Insertional/*GENETICS Retrotransposons/*GENETICS JOURNAL ARTICLE SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).