Document 0559
 DOCN  M9590559
 TI    HLA-DR expression on CD8 lymphocytes from gastric mucosa in
       urease-positive and urease-negative gastritis.
 DT    9509
 AU    Ihan A; Krizman I; Ferlan-Marolt V; Tepez B; Gubina M; Institute of
       Microbiology, Medical Faculty, Ljubljana, Slovenia.
 SO    FEMS Immunol Med Microbiol. 1995 Feb;10(3-4):295-9. Unique Identifier :
       AIDSLINE MED/95291272
 AB    We isolated lymphocytes from chronically inflamed gastric mucosa. We
       analysed the expression of IL-2 receptors (CD25), transferin receptors
       (CD71) and HLA-DR molecules on T lymphocytes by flow cytometric analysis
       in 16 patients with urease-positive and in 7 patients with
       urease-negative chronic gastritis. In G0, G1 and G2 histological type
       (Sydney classification) of gastritis the number of lymphocytes obtained
       from the gastric mucosa biopsies was too low for the flow cytometric
       analysis. However, in G3 histological type of chronic gastritis we
       obtained enough cells for the flow cytometric analysis in 75%. We
       demonstrated a significant increase in HLA-DR expression on CD8 cells
       from patients with urease-positive gastritis compared to urease-negative
       gastritis. We also observed a statistically non-significant increase in
       HLA-DR expression on CD3 cells, and in CD71 expression on both CD3 and
       CD8 cells in urease-positive gastritis. However, no difference in CD25
       expression was found between the two types of gastritis.
 DE    Antigens, CD3/BIOSYNTHESIS  Chronic Disease  Comparative Study
       CD8-Positive T-Lymphocytes/*IMMUNOLOGY  Female  Flow Cytometry  Gastric
       Mucosa/CYTOLOGY/IMMUNOLOGY/PATHOLOGY  Gastritis/*IMMUNOLOGY
       Helicobacter pylori/IMMUNOLOGY/PATHOGENICITY  Helicobacter
       Infections/IMMUNOLOGY  Human  HLA-DR Antigens/*BIOSYNTHESIS  Lymphocyte
       Count  Male  Receptors, Interleukin-2/BIOSYNTHESIS  Receptors,
       Transferrin/BIOSYNTHESIS  Urease/*METABOLISM  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).