Document 0566
 DOCN  M9590566
 TI    Clonal outgrowths of T and B cells in SCID mice reconstituted with cells
       from mice with MAIDS.
 DT    9509
 AU    Tang Y; Chattopadhyay SK; Hartley JW; Fredrickson TN; Morse HC 3rd;
       Laboratory of Immunopathology, National Institute of Allergy and;
       Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892,
       USA.
 SO    In Vivo. 1994 Nov-Dec;8(6):953-9. Unique Identifier : AIDSLINE
       MED/95290654
 AB    Murine acquired immunodeficiency syndrome (MAIDS), induce in mice by a
       defective murine retrovirus (BM5def), is characterized by development of
       severe immunodeficiency and polyclonal lymphoid proliferation which
       progress to yield oligoclonal populations of T and B cells. Oligoclonal
       populations transferred to SCID mice grew as clonal CD4+ T cell or B
       cell lineage transplants having one or more unique clonal integrations
       of BM5def. In some cases, spleens of single donor mice were shown to
       contain both B cell and T cell lineage clones that could be transferred
       individually after separation and were clonally unrelated. Successful
       transplants were obtained from oligoclonal populations as early as 63
       days after infection. Mouse strains both sensitive or moderately
       resistant to MAIDS yielded clonal transplants.
 DE    Animal  B-Lymphocytes/*IMMUNOLOGY/TRANSPLANTATION  Cell Division  Clone
       Cells  Lymphoma/ETIOLOGY/IMMUNOLOGY  Mice  Mice, Inbred BALB C  Mice,
       Inbred CBA  Mice, Inbred C57BL  Mice, SCID  Murine Acquired
       Immunodeficiency Syndrome/COMPLICATIONS/  *IMMUNOLOGY  Support, U.S.
       Gov't, P.H.S.  T-Lymphocytes/*IMMUNOLOGY/TRANSPLANTATION  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).