Document 0570
 DOCN  M9590570
 TI    Community treatment of HIV-1: initial stage and asymptotic dynamics.
 DT    9509
 AU    Hsieh YH; Velasco-Hernandez JX; Department of Applied Mathematics
       National Chung-Hsing; University, Taichung, Taiwan ROC.
 SO    Biosystems. 1995;35(1):75-81. Unique Identifier : AIDSLINE MED/95290630
 AB    Treatment with antiviral drugs (zidovudine and ddI) has been reported to
       delay progression to AIDS, and may even possibly lower the
       infectiousness of the infectives. However, its effect on the community
       level is still uncertain. The latter is important since a successful
       community treatment program must meet both public health and individual
       health goals. Our study will focus on the effect of a community-wide
       treatment program initiated at the early stages of the disease as well
       as the long-term effect of the program. Using a simple mathematical
       model, we demonstrate that a community-wide treatment program could be
       instrumental in decreasing HIV incidence rate and eradicating the
       disease in the future if certain conditions on the parameters are met.
       On the other hand, when the above mentioned conditions on the parameters
       are not satisfied, we show that even if the treatment does improve
       survival in AIDS patients and decrease the rate at which HIV infection
       spreads in the community, it is still possible for the treatment program
       to have an adverse effect on the spread of AIDS in the population in the
       long run. Hence, a public health policy maker must exercise caution in
       order to design an effective treatment program for HIV/AIDS.
 DE    *Community Health Services  Didanosine/THERAPEUTIC USE  Human  HIV
       Infections/*DRUG THERAPY/PREVENTION & CONTROL/TRANSMISSION  *HIV-1  Male
       Mathematics  Models, Biological  Support, Non-U.S. Gov't  Support, U.S.
       Gov't, Non-P.H.S.  Zidovudine/THERAPEUTIC USE  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).