Document 0583
 DOCN  M9590583
 TI    Cytotoxic ent-kaurene diterpenoids from three Isodon species.
 DT    9509
 AU    Sun HD; Lin ZW; Niu FD; Lin LZ; Chai HB; Pezzuto JM; Cordell GA;
       Laboratory of Phytochemistry, Kunming Institute of Botany,; Academia
       Sinica, Yunnan Province, P.R. China.
 SO    Phytochemistry. 1995 Jan;38(2):437-42. Unique Identifier : AIDSLINE
       MED/95290150
 AB    From Isodon loxothyrsa, one new diterpenoid, loxothyrin A, together with
       one known diterpenoid, adenolin B, from I.pleiophyllus, three known
       diterpenoids, coetsoidins A, B and G, and from I. adenoloma, one known
       diterpenoid, longikaurin F, were isolated. The structure determination
       of loxothyrin A, and the unambiguous NMR spectral assignments of the
       known compounds were made by a combination of 1D and 2D NMR techniques
       and computer modelling calculations. The isolates showed potent
       cytotoxic activities.
 DE    Antimalarials/CHEMISTRY/ISOLATION & PURIF/PHARMACOLOGY  Antineoplastic
       Agents, Phytogenic/CHEMISTRY/ISOLATION & PURIF/  PHARMACOLOGY
       Diterpenes/CHEMISTRY/*ISOLATION & PURIF/PHARMACOLOGY  HIV-1/ENZYMOLOGY
       Nuclear Magnetic Resonance  Plants/*CHEMISTRY  Reverse
       Transcriptase/ANTAGONISTS & INHIB  Support, Non-U.S. Gov't  Support,
       U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).