Document 0653
 DOCN  M9590653
 TI    Roxithromycin. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003.
       800-458-5231 ext. 5023.
 DT    9509
 SO    Notes Undergr. 1995 Winter;(no 29):3-4. Unique Identifier : AIDSLINE
       AIDS/95700302
 AB    The PWA Health Group now distributes roxithromycin (Ruclid) for
       cryptosporidiosis. Cryptosporidium parvum is a single-cell parasite that
       produces chronic watery diarrhea in people with compromised immune
       systems. Roxithromycin, a macrolide antibiotic, currently is used
       extensively in Europe and Latin America to treat a number of bacterial
       infections, including chlamydia, sinusitis, and skin and respiratory
       problems. At the 1994 International AIDS Conference, reports of two
       clinical studies showed that roxithromycin might effectively treat
       cryptosporidiosis. In both studies, patients took 300 mg of Roxy twice a
       day. In one study, complete clearance was seen in 5 patients, with
       improvement in 3 patients. Side effects of the drug seem to be minimal.
       One major concern is the possibility of elevated liver enzymes.
 DE    AIDS-Related Opportunistic Infections/*DRUG THERAPY  Clinical Trials
       Cryptosporidiosis/*DRUG THERAPY  Feces/PARASITOLOGY  Human
       Liver/ENZYMOLOGY  Roxithromycin/ADVERSE EFFECTS/*THERAPEUTIC USE
       NEWSLETTER ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).