Document 0705
 DOCN  M9590705
 TI    The future possibilities and current realities of soluble low molecular
       weight synthetic combinatorial libraries: a revolution in basic research
       and drug discovery
 DT    9509
 AU    Houghten RA; Appel J; Blondelle S; Dooley C; Eichler J; Pinilla C;
       Houghten Pharmaceuticals, Torrey Pines Institute for Molecular; Studies
 SO    NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session III, speakers'
       abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920014
 AB    The technology of soluble synthetic combinatorial libraries (SCLs) and
       synthetic peptide combinatorial libraries (SPCLs) [Nature 354:84-85,
       1991], which are made up of tens of millions of different compounds, is
       revolutionizing the drug discovery process. Recent developments permit
       the screening of billions of compounds to be carried out in as little as
       a single day [Bio Techniques 13:901-905, 1992]. Specific examples will
       be presented which utilize SCLs and SPCLs for the identification of
       highly active individual compounds in: 1) immunochemical studies in
       which antigenic determinants of peptides and proteins are identified; 2)
       the development of a wide range of new antibiotic and antifungal agents
       against E. coli, S. aureus, P. aeruginosa, and C. albicans; 3) the
       generation of novel agonist and antagonists using radioreceptor assays,
       illustrated for the opioid receptor systems; 4) the development of new
       enzyme inhibitors; and/or 5) the direct in vivo determination of
       compounds having potent hemodynamic properties. These methods have broad
       utility in all areas of biomedical research, and are useful for the
       rapid development of new, pharmacologically relevant small molecule lead
       compounds.
 DE    Antifungal Agents  Antigenic Determinants  Candida albicans/DRUG EFFECTS
       *Drug Design  Enzyme Inhibitors  Escherichia coli/DRUG EFFECTS
       Hemodynamics/DRUG EFFECTS  Molecular Weight  Peptides/IMMUNOLOGY
       Proteins/IMMUNOLOGY  Pseudomonas aeruginosa/DRUG EFFECTS  Receptors,
       Opioid/AGONISTS/ANTAGONISTS & INHIB  Research  Solubility
       Staphylococcus aureus/DRUG EFFECTS  MEETING ABSTRACT

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