Document 0724
 DOCN  M9590724
 TI    Multiple false reactions in viral antibody screening assays after
       influenza vaccination.
 DT    9509
 AU    Simonsen L; Buffington J; Shapiro CN; Holman RC; Strine TW; Grossman BJ;
       Williams AE; Schonberger LB; Division of Viral and Rickettsial Diseases,
       Centers for Disease; Control and Prevention, Atlanta, GA 30333, USA.
 SO    Am J Epidemiol. 1995 Jun 1;141(11):1089-96. Unique Identifier : AIDSLINE
       MED/95289357
 AB    In December 1991, US blood centers reported an unusual increase in
       donations that tested falsely reactive for antibodies to two or more
       (multiple false positive) of the following viruses: human
       immunodeficiency virus type 1 (HIV-1), human T-cell lymphotrophic virus
       type I (HTLV-I), and hepatitis C virus. Many of these donations were
       from people who had recently received the 1991-1992 influenza vaccine,
       raising the possibility that this vaccine had somehow specifically
       caused the problem of multiple false reactivity. A case-control study of
       101 affected donors and 191 matched controls found that recent receipt
       of any brand of influenza vaccine was significantly associated with
       testing multiple false positive (p < 0.05), as was a history of recent
       acute illness (p < 0.05) and of allergies (p < 0.05). Surveillance for
       monthly rates of multiple reactive donations from May 1990 through
       December 1992 linked the seasonal cluster of multiple false-positive
       donations to the use of viral screening test kits thought to react
       nonspecifically to donor immunoglobulin M. There was no similar increase
       in multiple false-positive donations during the 1992-1993 influenza
       vaccination season after the HIV-1 and hepatitis C virus tests were
       replaced; however, the number of donations that were falsely reactive
       for only HTLV-I almost doubled, indicating that false reactivity was not
       specifically associated with the 1991-1992 influenza vaccine. Retesting
       of affected donors found that the duration of HTLV-I and hepatitis C
       virus false reactivity was 3-6 months. The cluster of multiple
       false-positive donations in 1991 was most likely caused by the test kits
       used, rather than by the influenza vaccine.
 DE    Adolescence  Adult  Aged  Analysis of Variance  *Blood Donors
       Case-Control Studies  Cluster Analysis  Confidence Intervals  False
       Positive Reactions  Female  Hepatitis Antibodies/*BLOOD  Hepatitis C
       Viruses/*IMMUNOLOGY  Human  HIV Antibodies/*BLOOD  HTLV-I
       Antibodies/*BLOOD  Immunoenzyme Techniques  Influenza
       Vaccine/*IMMUNOLOGY  Male  Middle Age  Odds Ratio  Prevalence
       Regression Analysis  Retrospective Studies  Risk Factors  Seasons  Time
       Factors  United States/EPIDEMIOLOGY  JOURNAL ARTICLE  MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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