Document 0729
 DOCN  M9590729
 TI    Intestinal spirochetosis and acquired immunodeficiency syndrome:
       ultrastructural studies of two cases.
 DT    9509
 AU    Guccion JG; Benator DA; Zeller J; Termanini B; Saini N; Pathology and
       Laboratory Medicine Service (113), Department of; Veterans Affairs
       Medical Center, Washington, DC 20422, USA.
 SO    Ultrastruct Pathol. 1995 Jan-Feb;19(1):15-22. Unique Identifier :
       AIDSLINE MED/95288830
 AB    Two cases of intestinal spirochetosis (IS) with acquired
       immunodeficiency syndrome are reported. In case 1, a 48-year-old
       homosexual black man presented with a 1-month history of alternating
       watery diarrhea and constipation, which dissipated following the removal
       of two colonic hyperplastic polyps containing IS. In case 2, a
       26-year-old homosexual black man presented with a 3-month history of
       persistent bloody diarrhea and was found to have chronic shigellosis and
       IS. Pathologic findings of IS were similar in both cases. Basophilic
       fringes typical of IS covered the surfacing colonic epithelium and
       consisted of dense growths of spirochetes adherent to and oriented
       perpendicular to the plasma membranes of the surfacing epithelium. The
       spirochetes measured 3 to 5 microns in length and 0.2 micron in width,
       contained four to eight axial fibrils, and closely resembled Brachyspira
       aalborgi ultrastructurally. These cases are notable because the
       histopathologic changes of IS were more extensive than generally
       described. There was involvement of both the right colon and rectum by
       IS in case 2, and in both cases there was extension of the IS down into
       the crypts of Lieberkuhn, spirochetal invasion of the colonic mucosa,
       and a conspicuous inflammatory response by macrophages in the underlying
       lamina propria.
 DE    Adult  AIDS-Related Opportunistic Infections/MICROBIOLOGY/*PATHOLOGY
       Case Report  Colon/MICROBIOLOGY/*ULTRASTRUCTURE  Colonic
       Diseases/MICROBIOLOGY/*PATHOLOGY  Human  Intestinal
       Mucosa/MICROBIOLOGY/ULTRASTRUCTURE  Male  Middle Age
       Spirochaetales/GROWTH & DEVELOPMENT/*ULTRASTRUCTURE  Spirochaetales
       Infections/MICROBIOLOGY/*PATHOLOGY  JOURNAL ARTICLE

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