Document 0733
 DOCN  M9590733
 TI    [A comparative study of the expression of activation markers on
       T-lymphocyte subpopulations in different forms of bronchial asthma]
 DT    9509
 AU    Beda MV; Pavliuk AS; Veselova AV; Dement'eva EG; Solov'ev SS; Bart BIa;
       Koval'chuk LV
 SO    Ter Arkh. 1995;67(3):26-9. Unique Identifier : AIDSLINE MED/95288665
 AB    In this study we investigated a phenotype of intact and PHA-stimulated
       T-lymphocytes from peripheral blood of patients with allergic and
       nonallergic asthma. Expression of the activation markers (CD25, CD71,
       HLA-DR) on subsets of T-lymphocytes (CD4+ and CD8+) was determined using
       double-colour flow cytometry. It was found that nonallergic patients had
       increased percentages of CD4+CD25+, CD8+CD25+, CD4+HLA-DR+, CD8+HLA-DR+
       cells. Allergic patients had a significant increase of CD4+CD25+ cells
       only. To examine functional significance of these changes mononuclear
       cells were cultivated with PHA in vitro. Thus, our findings improve our
       knowledge about asthma pathogenesis and create the grounds for
       pathogenetically validated immunocorrection.
 DE    Adult  Antigens, CD/BLOOD  Antigens, Differentiation, B-Lymphocyte/BLOOD
       Asthma/*IMMUNOLOGY  Biological Markers/BLOOD  Chronic Disease
       Comparative Study  CD4-Positive T-Lymphocytes/*IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  English Abstract  Human  Hypersensitivity,
       Immediate/IMMUNOLOGY  HLA-DR Antigens/BLOOD  Immunophenotyping
       Lymphocyte Transformation/*IMMUNOLOGY  Middle Age  Receptors,
       Interleukin-2/ANALYSIS  JOURNAL ARTICLE

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