Document 0738
 DOCN  M9590738
 TI    Natural killer suppressor factors in sera from HIV-infected subjects.
 DT    9509
 AU    Goicoa MA; Sen L; Iannitelli PS; Diez RA; Estevez ME; Division
       Inmunologia Oncologica, Instituto de Investigaciones; Hematologicas
       Mariano R. Castex, Academia Nacional de Medicina,; Buenos Aires,
       Argentina.
 SO    Scand J Immunol. 1995 Jun;41(6):523-8. Unique Identifier : AIDSLINE
       MED/95288580
 AB    We investigated the presence of NK suppressor factors in HIV+ sera. We
       further investigated if gp120 could be one of the substances responsible
       for the impairment of NKC regulation found in HIV+ asymptomatic
       patients. Our results indicate that HIV+ sera inhibit significantly
       normal NKC in a dose-dependent way, even at concentrations as low as 1%.
       The inhibitory effect of HIV+ sera decreased, but was not completely
       removed, by adsorptions of IgG or by treatment with a MoAb against human
       FcIgG. Pretreatment of normal effector cells with anti-CD16 MoAb
       slightly reduced their cytotoxic capability, but did not modify the
       suppressor effect of HIV+ sera. The The preincubation of normal PBMC
       with recombinant gp120 had also a suppressor effect even at 10 ng/ml.
       Pretreatment of HIV+ sera with anti-gp120 or anti-FcIgG MoAb reduced,
       but not completely, their inhibitory effect. In conclusion, HIV+ serum
       has a dose-dependent inhibitory effect on normal NKC. Most of this
       inhibition is caused by IgG, but other substances, such as gp120, can
       also contribute to it. Since the removal of IgG and further treatments
       of HIV+ sera were not able to abrogate completely the NK suppression,
       other serum factors still undetermined (TNF-alpha, other cytokines),
       should be considered.
 DE    Adult  Cytotoxicity Tests, Immunologic  Human  HIV Envelope Protein
       gp120/*BLOOD  HIV Infections/*IMMUNOLOGY  HIV-1/IMMUNOLOGY  IgG/*BLOOD
       Killer Cells, Natural/*IMMUNOLOGY  Male  Recombinant Proteins/IMMUNOLOGY
       Support, Non-U.S. Gov't  Suppressor Factors, Immunologic/*BLOOD  JOURNAL
       ARTICLE

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