Document 0743
 DOCN  M9590743
 TI    [Persistent diarrhea in HIV infected patients: role of Enterocytozoon
       bieneusi]
 DT    9509
 AU    Bernard E; Carles M; Pradier C; Boissy C; Roger PM; Hebuterne X; Mondain
       V; Michiels JF; Le Fichoux Y; Dellamonica P; Service de Maladies
       infectieuses et tropicales, Hopital de; l'Archet, Nice.
 SO    Presse Med. 1995 Apr 8;24(14):671-4. Unique Identifier : AIDSLINE
       MED/95288236
 AB    OBJECTIVES: To determine the epidemiologic, clinical and aetiologic
       features of chronic diarrhoea in patients with human immunodeficiency
       virus (HIV) infection. METHODS: Between January 1992 and April 1993, all
       HIV positive patients with chronic diarrhoea were enrolled in a
       prospective study. There were 46 patients in the study group including
       33 (22 homosexuals) in stage C according to the 1993 Centers for Disease
       Control classification. RESULTS: Thirty-four pathogenic agents were
       isolated in 26 of the patients (57%). Enterocytozoon bieneusi was the
       most frequently found pathogen (11 patients, 24%) followed by
       Cryptosporidium sp (8 patients). Enterocytozoon bieneusi was found in
       association with other pathogens in 7 patients. All patients with
       microsporidiosis were in stage C (p = 0.04) and had a longer duration of
       diarrhoea (19.6 vs 9.8 weeks, p = 0.03), greater weight loss (9.6 vs 2.1
       kg, p = 0.0003) and a lower Karnofsky index (48% vs 67%, p = 0.01).
       Prophylaxy with dapsone or pyrimethamine during the 3 months prior to
       inclusion had been more frequent (p = 0.04 and p = 0.05 respectively) in
       patients without microsporidiosis. CONCLUSION: Microsporidiosis should
       be suspected as a probable cause of chronic diarrhoea in HIV positive
       patients with a CD4 count < 100/mm3. Multiple infections may be a factor
       leading to treatment failure. Microsporidiosis seems to be linked to
       homosexual intercourse.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  Animal
       AIDS-Related Opportunistic Infections/*PARASITOLOGY
       Cryptosporidiosis/*COMPLICATIONS/PARASITOLOGY
       Diarrhea/*ETIOLOGY/PARASITOLOGY  English Abstract  Female  Human  HIV
       Infections/*COMPLICATIONS/PARASITOLOGY  Male  Microspora
       Infections/*COMPLICATIONS/PARASITOLOGY  Microsporida/*ISOLATION & PURIF
       Middle Age  Prospective Studies  JOURNAL ARTICLE

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