Document 0750
 DOCN  M9590750
 TI    Differential receptive and expressive language functioning of children
       with symptomatic HIV disease and relation to CT scan brain
       abnormalities.
 DT    9509
 AU    Wolters PL; Brouwers P; Moss HA; Pizzo PA; Pediatric Branch, National
       Cancer Institute, National Institutes; of Health, Bethesda, MD, USA.
 SO    Pediatrics. 1995 Jan;95(1):112-9. Unique Identifier : AIDSLINE
       MED/95288107
 AB    OBJECTIVES. To investigate the effect of HIV disease on the receptive
       and expressive language of children and the relationship between CT scan
       brain abnormalities and language functioning. METHODS. Thirty-six
       children (mean age, 5.5 years; range, 1 through 10 years; 75% vertical
       transmission; 58% classified as encephalopathic) with symptomatic HIV
       infection and 20 uninfected siblings (mean age, 7.8 years; range, 3
       through 15 years) were administered an age-appropriate comprehensive
       language test assessing both receptive and expressive language (Reynell
       Developmental Language Scales or Clinical Evaluation of Language
       Fundamentals--Revised). Each HIV-infected child had a CT scan of the
       brain as part of the baseline evaluation, which was rated independently
       and blindly by two neurologists, for presence and severity of brain
       abnormalities using a semiquantitative rating system. RESULTS.
       Expressive language was significantly more impaired than receptive
       language in the overall sample of HIV-infected children. The
       encephalopathic children scored significantly lower than the
       non-encephalopathic children, however, the degree of discrepancy between
       mean receptive and expressive language scores was not significantly
       different between these two groups. The uninfected sibling control group
       did not have a significant discrepancy between receptive and expressive
       language, and they scored significantly higher than the infected patient
       group. Greater severity of CT scan abnormalities was significantly
       correlated with poorer receptive and expressive language functioning in
       the overall HIV-infected sample and a higher discrepancy between
       receptive and expressive language in the encephalopathic group.
       CONCLUSION. Pediatric HIV disease is associated with differential
       receptive and expressive language functioning in which expressive
       language is significantly more impaired than receptive language. The
       sibling data and CT scan correlations suggest that the observed language
       impairments are associated with the direct effects of HIV-related
       central nervous system disease.
 DE    Adolescence  AIDS Dementia
       Complex/CLASSIFICATION/*PSYCHOLOGY/RADIOGRAPHY  Brain/RADIOGRAPHY
       Case-Control Studies  Child  *Child Language  Child, Preschool
       Comparative Study  Female  Human  HIV Infections/DRUG
       THERAPY/*PSYCHOLOGY/RADIOGRAPHY/TRANSMISSION  Infant  Male  Support,
       U.S. Gov't, P.H.S.  Tomography, X-Ray Computed  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).