Document 0752
 DOCN  M9590752
 TI    Torulopsis glabrata vaginitis.
 DT    9509
 AU    Spinillo A; Capuzzo E; Egbe TO; Baltaro F; Nicola S; Piazzi G; Clinica
       Ostetrico-Ginecologica, IRCCS Policlinico San Matteo,; Universita di
       Pavia, Italy.
 SO    Obstet Gynecol. 1995 Jun;85(6):993-8. Unique Identifier : AIDSLINE
       MED/95288092
 AB    OBJECTIVE: To study the sociodemographic risk factors and clinical
       features of Torulopsis glabrata vaginal infection. METHODS: We evaluated
       the sociodemographic and clinical characteristics of 86 consecutive
       symptomatic women attending a vaginitis clinic and isolated T glabrata.
       Case patients were compared with a control group of 174 asymptomatic
       women with negative vaginal cultures and an additional group of 625
       symptomatic women with vaginal cultures positive for Candida albicans.
       In addition, the sensitivity of the isolates to the more common
       antimycotic agents used was tested by the modified Kirby-Bauer method.
       RESULTS: Patients with T glabrata vaginal infection were from lower
       socioeconomic backgrounds and had less education. They were more likely
       to use vaginal tampons and to be seropositive for human immunodeficiency
       virus than were negative controls. Compared with C albicans infection, T
       glabrata was more frequent among women over 38 years of age and in those
       with less education and of lower social class. In logistic regression
       analysis, T glabrata was associated more frequently with recurrent
       vaginal candidiasis than was C albicans (odds ratio 2.46, 95% confidence
       interval 1.33-4.54; P = .004). Six of the 86 (7%) T glabrata isolates
       and none of the C albicans isolates (P < .001 by Fisher exact test) were
       resistant to the imidazole derivatives tested. CONCLUSION: Torulopsis
       glabrata was isolated in 10% of women with vulvovaginal candidiasis
       attending a vaginitis clinic. This infection was associated with
       recurrent vaginitis in almost one-third of case patients presenting with
       symptoms.
 DE    Adult  Candidiasis, Vulvovaginal/*EPIDEMIOLOGY  Case-Control Studies
       Confidence Intervals  Female  Human  Logistic Models  Odds Ratio  Risk
       Factors  Sensitivity and Specificity  Socioeconomic Factors
       Vaginitis/*EPIDEMIOLOGY/MICROBIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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