Document 0782
 DOCN  M9590782
 TI    Evidence that measles virus hemagglutinin initiates modulation of
       leukocyte function-associated antigen 1 expression.
 DT    9509
 AU    Nagendra AR; Smith CW; Wyde PR; Department of Microbiology and
       Immunology, Baylor College of; Medicine, Houston, Texas 77030, USA.
 SO    J Virol. 1995 Jul;69(7):4357-63. Unique Identifier : AIDSLINE
       MED/95287491
 AB    Measles virus (MV), human immunodeficiency virus, Epstein-Barr virus,
       and other leukotropic viruses can modulate the expression of leukocyte
       function antigen 1 (LFA-1) on the surface of infected and nearby
       leukocytes. This ability to induce changes in LFA-1 expression may play
       an important role in the pathogenesis of these viruses. However, the
       mechanism(s) involved in virus-mediated regulation of LFA-1 is unknown.
       Evidence is presented in this report that it is the MV hemagglutinin (H)
       protein that initiates up-regulation of LFA-1 expression in leukocyte
       cultures infected with this virus. Indeed, comparison of the abilities
       of different MV strains to modulate LFA-1 expression, examination of
       published nucleotide sequences for the H proteins of different vaccine
       strains, and competitive inhibition assays using oligopeptides
       homologous or heterologous to a region of the H protein gene
       encompassing amino acid 116 (from the amino terminus) all suggest that
       it is this portion of the H protein that is responsible for MV-induced
       alteration of LFA-1. These comparisons also support the hypothesis that
       there is a relationship between the abilities of different MV strains to
       alter LFA-1 expression and their pathogenic potentials.
 DE    Amino Acid Sequence  Animal  Antibodies, Monoclonal/IMMUNOLOGY  Cell
       Aggregation  Cells, Cultured  Cercopithecus aethiops  Hemagglutinins,
       Viral/GENETICS/*PHYSIOLOGY  Human  Lymphocyte Function-Associated
       Antigen-1/*ANALYSIS  Measles Virus/*PHYSIOLOGY  Molecular Sequence Data
       Oligopeptides/PHARMACOLOGY  Support, U.S. Gov't, P.H.S.  Vero Cells
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).