Document 0788
 DOCN  M9590788
 TI    Effects of exogenous, nonleukemogenic, ecotropic murine leukemia virus
       infections on the immune systems of adult C57BL/6 mice.
 DT    9509
 AU    Lee JS; Giese NA; Elkins KL; Yetter RA; Holmes KL; Hartley JW; Morse HC
       3rd; Laboratory of Immunopathology, National Institute of Allergy and;
       Infectious Diseases, Bethesda, Maryland 20892, USA.
 SO    J Virol. 1995 Jul;69(7):4182-8. Unique Identifier : AIDSLINE
       MED/95287470
 AB    Mouse AIDS (MAIDS) develops in mice infected with a mixture of
       replication-competent ecotropic and mink lung cell focus-inducing murine
       leukemia viruses and an etiologic replication-defective virus. Helper
       viruses are not required for induction of MAIDS, but the time course of
       disease is accelerated in their presence. To understand the possible
       contributions of ectropic murine leukemia viruses to MAIDS pathogenesis,
       we biologically cloned a series of viruses from the MAIDS-inducing
       LP-BM5 virus mixture. These viruses were examined for replication in
       tissues of infected mice and for effects on the immune system. All virus
       stocks replicated efficiently in mice. Infected animals showed slight
       lymphadenopathy and splenomegaly due primarily to B-cell proliferation
       associated with differentiation to immunoglobulin secretion resulting in
       twofold increases in serum immunoglobulin M levels; however, B-cell
       responses to helper T-cell-independent antigens were increased rather
       than decreased as in MAIDS. Analyses of CD8+ T-cell function showed that
       cytotoxic T-lymphocyte responses to alloantigens were comparable in
       control and infected mice. Finally, we showed that infection resulted in
       enhanced expression of transcripts for interleukin-10, interleukin-4,
       and gamma interferon. These cytokines can all contribute to B-cell
       activation and may promote the expansion of a target cell population for
       the MAIDS defective virus.
 DE    Animal  B-Lymphocytes/IMMUNOLOGY  Cytokines/BIOSYNTHESIS
       IgM/BIOSYNTHESIS  Leukemia Viruses, Murine/*IMMUNOLOGY  Lymphocyte
       Transformation  Mice  Mice, Inbred CBA  Mice, Inbred C57BL  Murine
       Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Retroviridae
       Infections/*IMMUNOLOGY  Spleen/VIROLOGY  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  T-Lymphocytes, Cytotoxic/IMMUNOLOGY  Tumor
       Virus Infections/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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