Document 0803
 DOCN  M9590803
 TI    HEp-2 cell-adherent Escherichia coli in patients with human
       immunodeficiency virus-associated diarrhea.
 DT    9509
 AU    Mathewson JJ; Jiang ZD; Zumla A; Chintu C; Luo N; Calamari SR; Genta RM;
       Steephen A; Schwartz P; DuPont HL; Center for Infectious Diseases,
       University of Texas Medical; School/School of Public Health, Houston
       77030, USA.
 SO    J Infect Dis. 1995 Jun;171(6):1636-9. Unique Identifier : AIDSLINE
       MED/95287065
 AB    Diarrhea occurs commonly in African human immunodeficiency virus (HIV)
       infections. A case-control (HIV-positive vs. -negative) study of adults
       with diarrhea was done in Lusaka, Zambia, to determine the prevalence of
       intestinal infection by HEp-2 cell-adherent Escherichia coli. Adherent
       E. coli were more common in HIV-positive patients with acute diarrhea
       than among HIV-negative controls (60% vs. 33%) and were found
       significantly more often in HIV-positive patients with chronic diarrhea
       than among HIV-negative controls with chronic diarrhea (79% vs. 17%, P <
       .002). Adherent strains were found significantly more often among
       HIV-positive patients (69%) than in 22 asymptomatic subjects (36%, P <
       .02). The HEp-2 cell adherence of the E. coli strains did not show a
       common pattern. Adherent bacteria were also observed in colonic biopsies
       from 32% of Zambians with chronic diarrhea who underwent endoscopy.
       Adherent E. coli may be an important cause of HIV-associated diarrhea in
       Zambia.
 DE    Acute Disease  Adhesins, Escherichia coli/GENETICS  Adolescence  Adult
       *Bacterial Adhesion  Carcinoma, Hepatocellular  Case-Control Studies
       Cell Line  Chronic Disease  Diarrhea/*COMPLICATIONS/MICROBIOLOGY
       Escherichia coli/GENETICS/*PATHOGENICITY  Human  HIV
       Seropositivity/*COMPLICATIONS/MICROBIOLOGY  Tumor Cells, Cultured
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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