Document 0808
 DOCN  M9590808
 TI    Human immunodeficiency virus type 1 p24 antigen in cervicovaginal
       secretions.
 DT    9509
 AU    Belec L; Matta M; Payan C; Gresenguet G; Tevi-Benissan C; Pillot J;
       Unite d'Immunologie Microbienne, Institut Pasteur, Paris,; France.
 SO    J Infect Dis. 1995 Jun;171(6):1615-8. Unique Identifier : AIDSLINE
       MED/95287060
 AB    The failure to detect human immunodeficiency virus (HIV) antigen in
       cervicovaginal secretions (CVS) from HIV-infected women could be due in
       part to an in situ formation of immune complexes involving HIV antigens
       and cervicovaginal anti-HIV antibodies. CVS from 30 HIV-1-infected
       heterosexual women were assayed for p24 antigen detection by ELISA
       before and after acid disruption of immune complexes. Before acid
       treatment, free p24 antigen was detected in only 1 sample of CVS,
       whereas after acid dissociation, 4 (13.5%) of 30 samples had detectable
       and neutralizable p24 antigen. Adsorbent capacities of the CVS for
       recombinant p24 antigen, evaluated in an in vitro model, depended on
       both titer and avidity of cervicovaginal antibodies to HIV. In
       conclusion, local antibodies to HIV are able in vivo to bind HIV antigen
       within CVS and to participate in the immune exclusion of free virus
       particles or proteins.
 DE    Adolescence  Adult  Antigen-Antibody Complex/METABOLISM  Cervix
       Uteri/*SECRETION  Exudates and Transudates/IMMUNOLOGY  Female  Human
       HIV Antibodies/METABOLISM  HIV Antigens/METABOLISM  HIV Core Protein
       p24/IMMUNOLOGY/*METABOLISM  HIV Infections/*IMMUNOLOGY  Support,
       Non-U.S. Gov't  Vagina/*SECRETION  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).