Document 0822
 DOCN  M9590822
 TI    Association between maternal antibodies to the external envelope
       glycoprotein and vertical transmission of human T-lymphotropic virus
       type I. Maternal anti-env antibodies correlate with protection in
       non-breast-fed children.
 DT    9509
 AU    Hino S; Katamine S; Miyamoto T; Doi H; Tsuji Y; Yamabe T; Kaplan JE;
       Rudolph DL; Lal RB; Department of Virology, Faculty of Medicine, Tottori
       University,; Yonago, Japan.
 SO    J Clin Invest. 1995 Jun;95(6):2920-5. Unique Identifier : AIDSLINE
       MED/95286861
 AB    Vertical transmission of human T-lymphotropic virus type I (HTLV-I)
       depends primarily on breast-feeding; substitution of bottle-feeding has
       reduced the transmission rate from 20% in breast-fed children to 3%
       among bottle-fed. To determine the correlates of transmission for long
       breast-feeding (> or = 6 mo), short breast-feeding (< 6 mo), and
       bottle-feeding mothers, the antibody titers of transmitter (T) mothers
       and non-transmitter (nT) mothers were analyzed by using synthetic and
       recombinant epitopes representing the immunodominant epitopes of gag
       (Gag1a, r24), env (Env1/5, MTA1, RE3), and tax (Tax8/22-24) proteins.
       Seroreactivity to gag and tax epitopes was not significantly different
       except for anti-r24 antibody titer, which was significantly higher among
       T-mothers (geometric mean 134) when compared with nT-mothers (62) in the
       long-feeding group (P < 0.001). Profiles of antibody titers against env
       epitopes were different. Within the long-feeding group, Env1/5, MTA1,
       and RE3 titers were significantly higher among T-mothers (258, 1,476,
       and 738, respectively) when compared with nT-mothers (106, 279, and 320,
       respectively) (P < 0.01 for all three epitopes). In contrast, within the
       bottle-feeding group, antibody titers to Env1/5 (269) and RE3 (418)
       among nT-mothers were significantly higher than those among T-mothers
       (80 and 113, respectively) (P < 0.01). These data confirm that
       high-titered anti-HTLV-I antibodies in the long-feeding group correlate
       with milk-borne transmission of HTLV-I and, more importantly, imply that
       maternal anti-env antibodies may reduce the risk of non-milkborne
       infection.
 DE    Amino Acid Sequence  Breast Feeding  Female  Gene Products,
       env/*IMMUNOLOGY  Gene Products, gag/IMMUNOLOGY  Human  HTLV-BLV
       Antibodies/*IMMUNOLOGY  HTLV-BLV Antigens/IMMUNOLOGY  HTLV-I/*IMMUNOLOGY
       HTLV-I Infections/*TRANSMISSION  Membrane Glycoproteins/IMMUNOLOGY
       Milk, Human/IMMUNOLOGY  Molecular Sequence Data
       Peptides/CHEMISTRY/IMMUNOLOGY  Pregnancy  Support, Non-U.S. Gov't
       Support, U.S. Gov't, Non-P.H.S.  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).