Document 0843
 DOCN  M9590843
 TI    Autoreactivity in HIV-1 infection: the role of molecular mimicry.
 DT    9509
 AU    Silvestris F; Williams RC Jr; Dammacco F; Department of Biomedical
       Sciences and Human Oncology, University; of Bari, Italy.
 SO    Clin Immunol Immunopathol. 1995 Jun;75(3):197-205. Unique Identifier :
       AIDSLINE MED/95285607
 AB    Autoimmunity during HIV-1 infection may contribute to the
       immunopathogenesis of AIDS. Titers of autoantibodies to HLA molecules
       and other surface markers of CD4+ T cells appear to increase with the
       progression of disease and may correlate with lymphopenia. Other
       autoantibodies are directed at a number of regulatory molecules of the
       immune system. Genesis of autoreactivity may be related to structural
       homologies of HIV-1 env-products to such functional molecules involved
       in the control of self-tolerance. The most impressive similarities
       include the HLA-DR4 and DR2, the variable regions of TCR alpha-, beta-,
       and gamma-chain, the Fas protein, and several functional domains of IgG
       and IgA. Thus, HIV-1 infection may induce dysregulation leading to
       autoimmune response, through a number of molecular mimicry mechanisms.
       Pathogenicity of antibodies to T cells could also include the activation
       of membrane-to-nucleus signal transducers resulting in increased
       apoptosis. The evolution of autoimmune mechanisms during HIV-1 infection
       cannot exclude, however, progression to immunoproliferative malignancy,
       since aspects of oligoclonal immune response to HIV-1 components may
       occur in several autoimmune diseases which in some instances evolve to
       lymphoma.
 DE    Amino Acid Sequence  Autoantibodies/BIOSYNTHESIS
       Autoantigens/IMMUNOLOGY  *Autoimmunity  B-Lymphocytes/IMMUNOLOGY  Cross
       Reactions  Gene Products, env/IMMUNOLOGY  Gene Products, gag/IMMUNOLOGY
       Human  HIV Envelope Protein gp120/IMMUNOLOGY  HIV Infections/*IMMUNOLOGY
       HLA-D Antigens/IMMUNOLOGY  Lymphocyte Transformation  Molecular Sequence
       Data  Sjogren's Syndrome/IMMUNOLOGY  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE  REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).