Document 0860
 DOCN  M9590860
 TI    Lack of relationship between human immunodeficiency virus infection and
       systemic lupus erythematosus.
 DT    9509
 AU    Font J; Vidal J; Cervera R; Lopez-Soto A; Miret C; Jimenez de Anta MT;
       Ingelmo M; Department of Internal Medicine, Hospital Clinic, Barcelona,;
       Catalonia, Spain.
 SO    Lupus. 1995 Feb;4(1):47-9. Unique Identifier : AIDSLINE MED/95284837
 AB    The objective of this work was to determine whether HIV-1 and HIV-2
       could be involved in the pathogenesis of systemic lupus erythematosus
       (SLE). Seventy-five consecutive Caucasian patients with SLE presenting
       at one institution over a 2-year period were studied. Serum samples were
       surveyed for anti-HIV-1 antibodies by a commercial ELISA coated with
       HIV-1-p24. For confirmation, conventional immunoblots were performed
       with the following antigens: HIV-1-gp41, p31, p24 and p17 (recombinant)
       and HIV-2-gp36 (synthetic peptide). Additionally, Western blots with
       HIV-1-gp160, gp120, gp41, p65, p51, p24 and p18 bands were applied.
       Seventeen (23%) patients exhibited reactivity with HIV-1-p24 in the
       ELISA, but in the immunoblots and Western blots these sera samples were
       negative. Patients with SLE may exhibit a reactivity with HIV-1-p24 in
       the ELISA for HIV infection screening but not in the confirmatory blots.
       This false-positive reactivity is probably due to molecular mimicry
       between autoantigens and retroviruses or a contaminant or artefacts in
       the antigen preparation procedure.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/COMPLICATIONS/  *IMMUNOLOGY
       Adult  Enzyme-Linked Immunosorbent Assay  False Positive Reactions
       Female  Human  HIV Antibodies/*BLOOD  HIV Core Protein p24/IMMUNOLOGY
       *HIV-1  *HIV-2  IgG/BLOOD  Lupus Erythematosus,
       Systemic/BLOOD/COMPLICATIONS/*IMMUNOLOGY  Male  JOURNAL ARTICLE

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