Document 0889
 DOCN  M9590889
 TI    Cerebral single-photon emission computed tomography abnormalities in
       human immunodeficiency virus type 1-infected gay men without cognitive
       impairment.
 DT    9509
 AU    Sacktor N; Prohovnik I; Van Heertum RL; Dooneief G; Gorman J; Marder K;
       Todak G; Stern Y; Mayeux R; Gertrude H. Sergievsky Center, Columbia
       University, New York, NY; 10032, USA.
 SO    Arch Neurol. 1995 Jun;52(6):607-11. Unique Identifier : AIDSLINE
       MED/95283491
 AB    OBJECTIVE: To determine whether technetium Tc99m exametazime
       single-photon computed emission tomography (SPECT) can distinguish gay
       human immunodeficiency virus (HIV)-positive subjects, both with and
       without mild cognitive impairment, from gay HIV-negative control
       subjects. DESIGN: Twenty HIV-positive subjects (12 without cognitive
       impairment and eight with mild cognitive impairment) and 10 HIV-negative
       subjects underwent neurological, neuropsychological, magnetic resonance
       imaging, and technetium Tc 99m exametazime SPECT examinations. SETTING:
       Subjects were recruited from a natural history study of gay men with HIV
       infection. PATIENTS: Subjects from the cohort who had previously
       participated in a magnetic resonance imaging study were selected for the
       SPECT study. MAIN OUTCOME MEASURES: The SPECT scans were rated as
       abnormal if focal defects, confirmed by a horizontal profile analysis,
       were seen. RESULTS: Sixty-seven percent of HIV-positive subjects without
       cognitive impairment, 88% of HIV-positive subjects with mild cognitive
       impairment, and 20% of HIV-negative subjects had abnormal SPECT scans (P
       < .05 for both HIV-positive groups when each group was compared with
       HIV-negative subjects). CONCLUSION: Compared with gay HIV-negative
       control subjects, focal SPECT defects are seen with an increased
       frequency in HIV-positive gay men without cognitive impairment and in
       HIV-positive gay men with mild cognitive impairment.
 DE    Adolescence  Adult  AIDS Dementia Complex/RADIONUCLIDE IMAGING
       Brain/*RADIONUCLIDE IMAGING  Cognition Disorders/*COMPLICATIONS
       Homosexuality, Male  Human  HIV Infections/*COMPLICATIONS/RADIONUCLIDE
       IMAGING  HIV Seronegativity  *HIV-1  Male  Middle Age  Support, Non-U.S.
       Gov't  Support, U.S. Gov't, P.H.S.  *Tomography, Emission-Computed,
       Single-Photon  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).