Document 0890
 DOCN  M9590890
 TI    [Pyrido(3,2-e)(1,4)diazepines--synthesis and testing of anti-HIV-1
       activity]
 DT    9509
 AU    Gorlitzer K; Wilpert C; Rubsamen-Waigmann H; Suhartono H; Wang L;
       Immelmann A; Institut fur Pharmazeutische Chemie, Technischen
       Universitat; Braunschweig.
 SO    Arch Pharm (Weinheim). 1995 Mar;328(3):247-55. Unique Identifier :
       AIDSLINE MED/95283420
 AB    Starting from the commercially available 6-methyl-2-pyridylamine (1) the
       pyrido[3,2-e][1,4]diazepine 14a was synthesized in 12 steps with 7%
       total yield. 14a, the N-methyl derivative 14b, the thiolactam 15a, the
       amidine 16, and the 1,2,4-triazole 17 were tested for
       anti-HIV-1-activity. None of the compounds tested possesses antiviral
       activity comparable to that of zidovudine (3'-azido-3'-desoxythymidine =
       AZT).
 DE    Antiviral Agents/*CHEMICAL SYNTHESIS/PHARMACOLOGY  Azepines/*CHEMICAL
       SYNTHESIS/PHARMACOLOGY  English Abstract  Human  HIV-1/*DRUG EFFECTS
       Pyridines/*CHEMICAL SYNTHESIS/PHARMACOLOGY  Zidovudine/PHARMACOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).