Document 1078
 DOCN  M9591078
 TI    Potential use of a simplified method for determination of itraconazole
       levels in plasma and esophageal tissue by using high-performance liquid
       chromatography.
 DT    9509
 AU    Darouiche RO; Setoodeh A; Anaissie EJ; Department of Medicine, Veterans
       Affairs Medical Center, Houston,; TX 77030, USA.
 SO    Antimicrob Agents Chemother. 1995 Mar;39(3):757-9. Unique Identifier :
       AIDSLINE MED/95314217
 AB    A simplified high-performance liquid chromatography assay was developed
       for determination of itraconazole levels in plasma and esophageal tissue
       in four patients with AIDS who had been receiving daily oral doses of
       100 mg of itraconazole in solution for at least 3 weeks for therapy of
       esophageal candidiasis. Itraconazole levels were about three times
       higher in esophageal tissue than in plasma (means +/- standard errors of
       0.69 +/- 0.50 micrograms/g and 0.24 +/- 0.16 micrograms/ml,
       respectively; P = 0.04). This method is quick (it requires only 1 h for
       completion) and sensitive (the limits of detectability for itraconazole
       in plasma and esophageal tissue are 0.005 micrograms/ml and 0.01
       micrograms/g, respectively), and it can be reliably used in clinical and
       research settings (accuracy, > 95%; absolute recovery from biological
       samples, 80 to 90%; coefficient of variation, 3.3 to 6.6%).
 DE    Acquired Immunodeficiency Syndrome/METABOLISM  Chromatography, High
       Pressure Liquid  Double-Blind Method  Esophagus/*CHEMISTRY/METABOLISM
       Human  Itraconazole/BLOOD/*CHEMISTRY/PHARMACOKINETICS  CLINICAL TRIAL
       JOURNAL ARTICLE  RANDOMIZED CONTROLLED TRIAL

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