Document 1085
 DOCN  M9591085
 TI    [Adult T-cell leukemia associated with HTLV-1 in a HIV-2 seropositive
       African]
 DT    9509
 AU    Mahe A; Gessain A; Huerre M; Valensi F; Keita S; Bobin P; Institut
       Marchoux, Bamako, Republique du Mali.
 SO    Ann Dermatol Venereol. 1994;121(10):704-9. Unique Identifier : AIDSLINE
       MED/95314080
 AB    INTRODUCTION. The aim of this report is to describe an HIV-2
       seropositive patient from Mali who had adult-T cell Leukaemia/Lymphoma
       associated with HTLV-I infection. CASE REPORT. The patient presented
       with erythroderma and foliate lymphocyte leukaemia. Skin biopsy showed
       an epidermotropic lymphoma. Tumoural cells expressed a mature T-cell
       phenotype CD4+/CD25+. High anti-HTLV-I titers and the evidence of
       monoclonal integration of HTLV-I provirus within circulating lymphoid
       cells led to the confirmation of HTLV-I as the causal agent in tumour
       cell transformation. HIV-2 serology was positive. DISCUSSION.
       Sub-Saharan Africa is a vast reservoir of HTLV-I virus with at least 5
       million infected persons. Cases of adult-T cell Leukaemia/Lymphoma in
       Africans are exceptional. Lack of sufficient knowledge of the disease
       could partially explain this discrepancy. The main differential
       diagnosis in dermatology is primary T-cell lymphomas of the skin,
       particularly mycosis fungoides and Sezary syndrome.
 DE    Adult  Africa South of the Sahara  Case Report  Dermatitis,
       Exfoliative/ETIOLOGY/PATHOLOGY  English Abstract  Human  HIV
       Infections/*COMPLICATIONS  HIV Seropositivity  *HIV-1  *HIV-2
       Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/
       *COMPLICATIONS/PATHOLOGY  Male  Skin Neoplasms/*COMPLICATIONS/PATHOLOGY
       JOURNAL ARTICLE

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