Document 1086
 DOCN  M9591086
 TI    Magnetic resonance imaging measurement of gray matter volume reductions
       in HIV dementia.
 DT    9509
 AU    Aylward EH; Brettschneider PD; McArthur JC; Harris GJ; Schlaepfer TE;
       Henderer JD; Barta PE; Tien AY; Pearlson GD; Department of Psychiatry,
       Johns Hopkins University School of; Medicine, Baltimore, MD 21205, USA.
 SO    Am J Psychiatry. 1995 Jul;152(7):987-94. Unique Identifier : AIDSLINE
       MED/95313774
 AB    OBJECTIVE: The authors recently reported smaller basal ganglia volumes
       for patients with HIV-associated dementia than for HIV-infected patients
       without dementia and a seronegative comparison group. The purpose of the
       current study was to determine whether HIV dementia is associated with
       volume reductions in other brain regions. METHOD: The authors measured
       volumes of CSF and gray and white tissue on cranial magnetic resonance
       images from homosexual men who were 1) infected with HIV with
       HIV-associated dementia complex, 2) infected with HIV without dementia,
       and 3) HIV seronegative. RESULTS: Results suggest that loss of white
       matter occurs with HIV infection and is more severe in HIV-positive
       patients with dementia than in those without dementia. There was some
       generalized volume reduction in gray matter in HIV-positive demented
       patients, although group differences did not reach significance when
       adjusted for age. Volume of posterior cortex, however, was significantly
       smaller among HIV-positive patients with dementia than in either
       remaining group. There were no significant differences between
       HIV-positive nondemented patients and HIV-negative subjects in these
       regions. CONCLUSIONS: In conjunction with findings from previous
       research, the authors conclude that HIV dementia is associated with
       specific gray matter volume reduction in basal ganglia and posterior
       cortex, as well as with generalized volume reduction of white matter.
 DE    Adult  Atrophy  AIDS Dementia Complex/*DIAGNOSIS/PATHOLOGY  Basal
       Ganglia/ANATOMY & HISTOLOGY/PATHOLOGY  Brain/*ANATOMY &
       HISTOLOGY/PATHOLOGY  Cerebral Cortex/ANATOMY & HISTOLOGY/PATHOLOGY
       Cerebral Ventricles/ANATOMY & HISTOLOGY/PATHOLOGY  Comparative Study
       Homosexuality, Male  Human  HIV Seronegativity  *Magnetic Resonance
       Imaging  Male  Middle Age  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).