Document 1091
 DOCN  M9591091
 TI    A follow-up study of neuropsychological functioning in AIDS-patients.
       Prognostic significance and effect of zidovudine therapy.
 DT    9509
 AU    Karlsen NR; Reinvang I; Froland SS; Department of Behavioural and
       Psychomatic Medicine, National; Hospital, Oslo, Norway.
 SO    Acta Neurol Scand. 1995 Mar;91(3):215-21. Unique Identifier : AIDSLINE
       MED/95313528
 AB    Thirty-three patients with AIDS were subjected to neuropsychological and
       immunological testing with semi-annual examinations over a two year
       period. No patient had signs of opportunistic infections or neoplasms in
       the CNS. Patients who were neuropsychologically impaired at the time of
       AIDS diagnosis (n = 12) survived for a significantly shorter period than
       did the non-impaired subjects (n = 21), and neuropsychological function
       at first test had a significant predictive value concerning survival
       time. The poor prognosis associated with impaired neuropsychological
       status was seen also in patients treated with zidovudine (ZDV). Of the
       21 patients who started ZDV treatment shortly after the first
       neuropsychological examination, 12 were retested. Follow-up data showed
       that this group of patients had a significant improvement in
       neuropsychological functioning during the first 6 months. However, a
       decrease in performance was observed at second follow-up. In the group
       not treated with ZDV (n = 7), two initially normal patients developed
       signs of HIV-encephalopathy, while none of the initially normal
       ZDV-treated patients did so. This might suggest a prophylactic effect of
       ZDV on development of neuropsychological dysfunction. Changes in
       neuropsychological test results were correlated with changes in serum
       concentration of neopterin irrespective of ZDV treatment, suggesting
       that monocyte/macrophage activation may be involved in the pathogenesis
       of HIV-encephalopathy.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/DRUG THERAPY/
       MORTALITY  Adult  AIDS Dementia Complex/*DIAGNOSIS/*ETIOLOGY
       CD4-Positive T-Lymphocytes  CD8-Positive T-Lymphocytes  Follow-Up
       Studies  Human  HIV Seropositivity  Middle Age  *Neuropsychological
       Tests  Prognosis  Zidovudine/THERAPEUTIC USE  JOURNAL ARTICLE

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