Document 1092
 DOCN  M9591092
 TI    Epidural anaesthesia blocks changes in peripheral lymphocytes
       subpopulation during gastrectomy for stomach cancer.
 DT    9509
 AU    Hashimoto T; Hashimoto S; Hori Y; Nakagawa H; Hosokawa T; Department of
       Anaesthesiology, Kyoto Prefectural University of; Medicine, Japan.
 SO    Acta Anaesthesiol Scand. 1995 Apr;39(3):294-8. Unique Identifier :
       AIDSLINE MED/95313492
 AB    To examine the effects of surgery and anaesthesia on cell-mediated and
       humoral immunity, we investigated changes in subpopulations of
       peripheral T cells and B cells during gastrectomy. Twenty-one patients
       with gastric cancers who underwent total or subtotal gastrectomy were
       randomly assigned to receive thiopental/N2O general anaesthesia
       supplemented with either epidural (epidural group, n = 12) or
       enflurane(enflurane group, n = 9). The changes in peripheral lymphocyte
       subpopulations were detected and quantified using single and double
       label analysis of monoclonal antibodies against lymphocyte membrane
       surface markers (Leu series). Subpopulations were measured before
       induction, and 1 and 2 hours after skin incision. In the enflurane
       group, B cells (Leu12+), total T cells (Leu4+), inducer T cells (CD4+,
       Leu8+) and the CD4/CD8 ratio decreased and suppressor T cells (CD8+,
       Leu15+) increased significantly after skin incision. Whereas, the
       epidural group showed no change in the number of B cells and each T cell
       subpopulation during the study. These data suggest that epidural
       anaesthesia blocks the effect of stress induced by major surgery on
       fluctuation of peripheral lymphocyte subpopulations which may be
       associated with suppression of immunity.
 DE    Aged  *Anesthesia, Epidural  CD4-CD8 Ratio  Female  *Gastrectomy  Human
       Lymphocyte Subsets/*IMMUNOLOGY  Male  Middle Age  Stomach
       Neoplasms/*IMMUNOLOGY/*SURGERY  CLINICAL TRIAL  JOURNAL ARTICLE
       RANDOMIZED CONTROLLED TRIAL

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