Document 1094
 DOCN  M9591094
 TI    Does the HIV-1 manipulate immune network via gp120 immunoglobulin-like
       domain involving V3 loop?
 DT    9509
 AU    Metlas R; Veljkovic V; Laboratory for Multidisciplinary Research,
       Institute of Nuclear; Sciences VINCA, Beograd, Yugoslavia.
 SO    Vaccine. 1995 Mar;13(4):355-9. Unique Identifier : AIDSLINE MED/95313414
 AB    According to the multiple criteria used, the consensus sequences of
       HIV-1 gp120 and immunoglobulin heavy chain variable segment, which is
       more than 40 amino acids long, show structural similarities. We assume
       that this gp120 sequence might encode idiotopes. If this is the case
       then the particular idiotope-bearing gp120, either soluble or expressed
       in multiple form on the surface of the infected cell, can influence the
       immune response in idiotype(Id)-anti-Id fashion. This might be the
       mechanism by which HIV induces immunological abnormalities and it should
       be taken into consideration in vaccine production as suggested by the
       authors previously.
 DE    Amino Acid Sequence  Human  HIV Envelope Protein gp120/*IMMUNOLOGY
       HIV-1/*IMMUNOLOGY  Immunoglobulin Idiotypes/IMMUNOLOGY  Immunoglobulin
       Variable Region/*IMMUNOLOGY  Molecular Sequence Data
       T-Lymphocytes/IMMUNOLOGY  JOURNAL ARTICLE

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