Document 1097
 DOCN  M9591097
 TI    HIV-1 infection of primary human neuroblasts.
 DT    9509
 AU    Ensoli F; Cafaro A; Fiorelli V; Vannelli B; Ensoli B; Thiele CJ; Cell
       and Molecular Biology Section, National Cancer Institute,; National
       Institutes of Health, Bethesda, Maryland 20892, USA.
 SO    Virology. 1995 Jun 20;210(1):221-5. Unique Identifier : AIDSLINE
       MED/95313359
 AB    Central nervous system (CNS) disorders are frequent in HIV-1-infected
       individuals, particularly in newborns and children, and are accompanied
       by histological alterations resulting in neuronal loss. Although several
       tumor-derived neuroectodermal cell lines can be infected by HIV-1, it
       has been reported that primary neural cells cannot be infected after
       they differentiate. However, pediatric AIDS is often the result of HIV-1
       infection occurring during fetal development and early postnatal life,
       when neural cells are not yet differentiated. Here we show that primary
       cell cultures derived from the human fetal olfactory system which are
       representative of the developing CNS can be infected by both HIV-1
       strains, the monocyte-macrophagotropic BaL and the lymphotropic
       HTLV-IIIB, although they do not express the CD4 molecule. In addition,
       the levels of viral replication are higher with the HIV-1 BaL than with
       the IIIB isolate. These results suggest that (1) during development
       immature neurons are susceptible to HIV-1 infection; (2)
       monocyte-macrophagotropic HIV-1 strains may preferentially be involved
       in the productive infection of the nervous system; and (3) a
       mechanism(s) other than the CD4-mediated viral entry is responsible for
       HIV-1 infection of immature neurons.
 DE    Acquired Immunodeficiency Syndrome/PATHOLOGY/VIROLOGY  Antigens,
       CD/BIOSYNTHESIS  Antigens, CD4/BIOSYNTHESIS  Cell Line  Clone Cells
       Embryo  Epithelium/CYTOLOGY/VIROLOGY  Fetus  Gene Expression  Human
       HIV-1/*PHYSIOLOGY/PATHOGENICITY  Infant  Infant, Newborn  Kinetics
       Neuroectodermal Tumors  Neurons/CYTOLOGY/*VIROLOGY  Olfactory
       Mucosa/EMBRYOLOGY/INNERVATION  RNA, Messenger/BIOSYNTHESIS  Time Factors
       Tumor Cells, Cultured  *Virus Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).