Document 1101
 DOCN  M9591101
 TI    Disseminated toxoplasmosis and acquired immunodeficiency syndrome:
       diagnosis by transmission electron microscopy.
 DT    9509
 AU    Guccion JG; Benator DA; Gibert CL; Dave HP; Pathology and Laboratory
       Medicine Service, Department of Veterans; Affairs Medical Center,
       Washington, DC 20422, USA.
 SO    Ultrastruct Pathol. 1995 Mar-Apr;19(2):95-9. Unique Identifier :
       AIDSLINE MED/95313234
 AB    A 43-year-old, bisexual, black man with acquired immunodeficiency
       syndrome (AIDS), detected by CD4 lymphocyte criteria alone, presented
       with low-grade fever, chills, malaise, and watery diarrhea of 2 days'
       duration. Over the next 5 days, he developed a fulminant septicemia-like
       illness with progressive hypotension, disseminated intravascular
       coagulation, and very high serum lactic acid dehydrogenase (2,150 U/L)
       and serum creatine phosphokinase (5,395 U/L) levels, and died. The cause
       of this illness was not clinically apparent. A bone marrow biopsy
       performed on the day of his death revealed intracytoplasmic clusters of
       3 microns long, oval, basophilic organisms, the exact nature of which
       was not evident by light microscopy. The diagnosis of disseminated
       toxoplasmosis (DT) was made only after electron microscopic study of the
       bone marrow revealed organisms with features typical of Toxoplasma
       gondii tachyzoites. These features included a multilayered pellicle, a
       pointed anterior end containing a conoid, up to nine rhoptries, sparse
       micronemes, and a posterior end containing a nucleus. Some of the
       organisms had divided by internal budding or endodyogeny. This case
       illustrates the value of transmission electron microscopy in making the
       diagnosis of DT.
 DE    Adult  Animal  AIDS-Related Opportunistic
       Infections/*DIAGNOSIS/PATHOLOGY/  PARASITOLOGY  Bone
       Marrow/*PARASITOLOGY/ULTRASTRUCTURE  Case Report  Human  Male
       Microscopy, Electron  Toxoplasma/*ULTRASTRUCTURE
       Toxoplasmosis/*DIAGNOSIS/PATHOLOGY/PARASITOLOGY  JOURNAL ARTICLE

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