Document 1105
 DOCN  M9591105
 TI    HLA in familial and nonfamilial Mediterranean Kaposi's sarcoma in
       Greece.
 DT    9509
 AU    Kaloterakis A; Papasteriades C; Filiotou A; Economidou J; Hadjiyannis S;
       Stratigos J; Second Department of Medicine, University of Athens
       Medical; School, Greece.
 SO    Tissue Antigens. 1995 Feb;45(2):117-9. Unique Identifier : AIDSLINE
       MED/95313029
 AB    Fifty-four (54) unrelated patients with Mediterranean Kaposi's sarcoma
       (MKS) and 8 patients members of 4 unrelated families with familial MKS
       were serotyped for HLA-A,B and DR antigens. The diagnosis was
       histologically confirmed and all patients were negative for anti-HIV
       antibodies. An increased frequency of HLA-B18 (44.4% vs 14.2% in the
       controls, p < 0.001, RR = 4.8) and HLA-DR5 (57.6% vs 37.2% in the
       controls, p < 0.025, RR = 2.29) was observed in the group of patients
       with MKS. Seven (7) of the 8 family members with FMKS possessed HLA-DR5,
       and the affected members in the 3 families shared a common haplotype
       which included HLA-DR5. These findings support the hypothesis that
       genetic factors linked to HLA-DR5 antigen may contribute to the
       pathogenesis of MKS.
 DE    Adult  Aged  Aged, 80 and over  Disease
       Susceptibility/GENETICS/IMMUNOLOGY  Female  Greece/EPIDEMIOLOGY  Human
       HLA Antigens/*ANALYSIS/GENETICS  HLA-DR5 Antigen/ANALYSIS/GENETICS
       Incidence  Male  Middle Age  Prospective Studies  Sarcoma,
       Kaposi's/CLASSIFICATION/EPIDEMIOLOGY/*GENETICS/  IMMUNOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).