Document 1109
 DOCN  M9591109
 TI    Validity of the Quality of Well-Being Scale for persons with human
       immunodeficiency virus infection. HNRC Group. HIV Neurobehavioral
       Research Center.
 DT    9509
 AU    Kaplan RM; Anderson JP; Patterson TL; McCutchan JA; Weinrich JD; Heaton
       RK; Atkinson JH; Thal L; Chandler J; Grant I; Naval Hospital, San Diego,
       La Jolla, California, USA.
 SO    Psychosom Med. 1995 Mar-Apr;57(2):138-47. Unique Identifier : AIDSLINE
       MED/95312628
 AB    To evaluate the validity of the Quality of Well-Being Scale (QWB) for
       studies of patients with human immunodeficiency virus (HIV) disease, 514
       men were studied who were divided among four categories: Centers for
       Disease Control and Prevention (CDC) Group A (N = 272), CDC-B (N = 81),
       CDC-C (N = 47), and uninfected male controls (N = 114). The QWB and a
       variety of medical, neuropsychological, and biochemical measures were
       administered to all participants. When QWB scores were broken down by
       HIV group, the CDC-C group was significantly lower (.614) than the CDC-B
       (.679), CDC-A (.754), or control group (.801). The difference between
       Groups CDC-C and CDC-A was about .14 units of well-being, which suggests
       that individuals lose 1/7 equivalents of 1 well year of life for each
       year they are in Group CDC-C in comparison to the asymptomatic group
       (Group CDC-A). In comparison to the controls, this would equal a 1-year
       of life loss for each seven infected individuals. The QWB was shown to
       be significantly associated with CD4+ lymphocytes (p < .001), clinician
       ratings of neuropsychological impairment (p < .04), neurologists ratings
       of dysfunction (p < .001), and all subscales of the Profile of Mood
       States. Baseline QWB scores were significant prospective predictors of
       death over a median follow-up time of 30 months. Multivariate models
       demonstrated high covariation between predictors of QWB. It was
       concluded that the QWB is a significant correlate of biological,
       neuropsychological, neurological, psychiatric, and mortality outcomes
       for male HIV-infected patients.
 DE    Adult  AIDS Dementia Complex/DIAGNOSIS/MORTALITY/PSYCHOLOGY  CD4
       Lymphocyte Count  Follow-Up Studies  Human  HIV
       Infections/CLASSIFICATION/MORTALITY/*PSYCHOLOGY  Middle Age  Neurologic
       Examination  Neuropsychological Tests  Personality Inventory/*STATISTICS
       & NUMER DATA  Prospective Studies  Psychometrics  *Quality of Life
       Reproducibility of Results  *Sick Role  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  Survival Analysis  JOURNAL ARTICLE

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