Document 1118
 DOCN  M9591118
 TI    The role of CD4+ and CD8+ T cells in protective immunity to the murine
       nematode parasite Trichuris muris.
 DT    9509
 AU    Koyama K; Tamauchi H; Ito Y; Department of Parasitology, Kitasato
       University School of; Medicine, Kanagawa, Japan.
 SO    Parasite Immunol. 1995 Mar;17(3):161-5. Unique Identifier : AIDSLINE
       MED/95312323
 AB    The role of CD4+ and CD8+ T cells in protective immunity to Trichuris
       muris was studied in CD4+ or CD8+ or both CD4+ and CD8+ T cell-depleted
       BALB/c mice. To assess in vivo depletion of T-cell subsets, CD4+ and
       CD8+ T cells in the Peyer's patches, the mesenteric lymph nodes (MLN),
       and the spleens of mice treated with T cell-specific monoclonal
       antibodies (MoAbs) were analysed by FACS. CD4+ T cells were selectively
       depleted in mice injected with anti-CD4 MoAb i.p. and injection of
       anti-CD8 MoAb resulted in selective depletion of CD8+ T cells. The
       expulsion of T. muris was inhibited in CD4+ T cell-depleted mice and
       numerous worms were detected in the large intestine on days 14 and 21
       after infection, although no suppression of protective immunity to T.
       muris was observed in CD8+ T cell-depleted mice. Moreover, there was no
       difference in suppression of protective immunity to T. muris between
       CD4+ T cell-depleted and both CD4+ and CD8+ T cells play a central role
       in protective immunity to T. muris infection.
 DE    Animal  Antibodies, Monoclonal/PHARMACOLOGY  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY/*PHYSIOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY/*PHYSIOLOGY  Flow Cytometry  Immunity, Active
       Intestine, Large/PARASITOLOGY  Lymphocyte Depletion  Lymphoid
       Tissue/IMMUNOLOGY  Male  Mice  Mice, Inbred BALB C
       Trichuriasis/*IMMUNOLOGY  Trichuris/*IMMUNOLOGY/ISOLATION & PURIF
       JOURNAL ARTICLE

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