Document 1119
 DOCN  M9591119
 TI    Induction of CD4+ and CD8+ T cell responses in efferent lymph responding
       to Toxoplasma gondii infection: analysis of phenotype and function.
 DT    9509
 AU    Innes EA; Panton WR; Sanderson A; Thomson KM; Wastling JM; Maley S;
       Buxton D; Moredun Research Institute, Edinburgh, UK.
 SO    Parasite Immunol. 1995 Mar;17(3):151-60. Unique Identifier : AIDSLINE
       MED/95312322
 AB    The kinetics of induction of T cell responses were examined in efferent
       lymph from a node draining the site of a primary inoculation of
       Toxoplasma gondii. The numbers of T cells increased after infection, due
       initially to an expansion of the CD4+ T cell population followed by an
       increase in the number of CD8+ T cells which coincided with the peak
       lymphoblast response. Proliferative responses of CD4+ T cells to T.
       gondii antigen were detectable from day six after infection and immune
       efferent lymph cells inhibited the intracellular multiplication of T.
       gondii in vitro. Optimum inhibition was achieved using CD8+ T cells
       restimulated in vitro, and the effector function appeared to be directed
       preferentially against the autologous rather than the allogeneic
       infected target cell. The results provide unique information on the
       induction of immune responses to T. gondii in vivo and provide evidence
       that both CD4+ and CD8+ T cells are necessary for the development of
       protective immunity induced by the S48 strain of T. gondii which is used
       as a live vaccine in sheep.
 DE    Acute Disease  Animal  Antigens, Protozoan/IMMUNOLOGY  Cell Line
       CD4-Positive T-Lymphocytes/*IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Efferent Pathways  Female
       Fibroblasts/PARASITOLOGY  Immunophenotyping/VETERINARY  Lymph
       Nodes/CYTOLOGY/IMMUNOLOGY/PARASITOLOGY  Lymphocyte Count  Lymphocyte
       Transformation/IMMUNOLOGY  Sheep  Sheep
       Diseases/*IMMUNOLOGY/PARASITOLOGY  Support, Non-U.S. Gov't
       Toxoplasma/GROWTH & DEVELOPMENT/IMMUNOLOGY  Toxoplasmosis,
       Animal/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).