Document 1139
 DOCN  M9591139
 TI    Lymphoma associated with human immunodeficiency virus infection.
 DT    9509
 AU    Wang CY; Snow JL; Su WP; Department of Dermatology, Mayo Clinic
       Rochester, MN 55905, USA.
 SO    Mayo Clin Proc. 1995 Jul;70(7):665-72. Unique Identifier : AIDSLINE
       MED/95311497
 AB    OBJECTIVE: To describe lymphoma associated with human immunodeficiency
       virus (HIV) infection. DESIGN: A review of HIV-related lymphoma and its
       associated epidemiology, etiopathogenesis, and clinicopathologic
       characteristics is presented. Major studies of therapeutic regimens for
       HIV-related lymphoma are discussed. Factors that could contribute to a
       poor prognosis are summarized. RESULTS: Malignant lymphoma that develops
       in patients with HIV infection fulfills diagnostic criteria for the
       acquired immunodeficiency syndrome (AIDS). The incidence is increasing
       and varies by subtype of lymphoma, age, sex, race, and risk factors.
       B-cell hyperactivation is thought to contribute to the development of
       lymphoma. The mechanisms that may show transformed cell
       hyperproliferation and clonal expansion are HIV itself or other viruses
       (for example, Epstein-Barr virus), growth factors, aberrant oncogene or
       tumor-suppressor gene expression, and factors that induce genetic
       instability or DNA damage or alter host or viral genome repair.
       Treatment of HIV-related lymphoma is associated with toxicity,
       infectious complications, low rate of complete response, and brief
       median survival time. CONCLUSION: Persons with HIV-induced immune
       dysregulation have a high risk for the development of aggressive
       non-Hodgkin's lymphoma characterized by histologic evidence of a
       high-grade malignant process, B-cell phenotype, an unusual extranodal
       involvement, and a poor prognosis. The potential role of specific
       viruses, antiviral treatments, and other therapeutic strategies are
       future areas of investigation.
 DE    Human  HIV Infections/*COMPLICATIONS
       Lymphoma/EPIDEMIOLOGY/GENETICS/IMMUNOLOGY/PATHOLOGY/*VIROLOGY  Prognosis
       Survival Rate  JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

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