Document 1146
 DOCN  M9591146
 TI    CD4+ beta islet cell-reactive T cell clones that suppress autoimmune
       diabetes in nonobese diabetic mice.
 DT    9509
 AU    Akhtar I; Gold JP; Pan LY; Ferrara JL; Yang XD; Kim JI; Tan KN; Division
       of Pediatric Oncology, Dana-Farber Cancer Institute,; Boston,
       Massachusetts, USA.
 SO    J Exp Med. 1995 Jul 1;182(1):87-97. Unique Identifier : AIDSLINE
       GENBANK/M64239
 AB    We report the isolation of a panel of CD4+ T helper type 1 autoreactive
       T cell clones from the spleen of unprimed nonobese diabetic mice, a
       murine model of human insulin-dependent diabetes mellitus. The T cell
       clones express a diverse repertoire of T cell receptors, three of which
       recognize beta islet cell autoantigen(s). The islet cell-reactive T cell
       clones inhibit adoptive transfer of insulin-dependent diabetes mellitus
       and intraislet lymphocytic infiltration. The protective capacity of the
       T cell clones correlates with their ability to produce a novel
       immunoregulatory activity that potently inhibits in vitro allogeneic
       mixed lymphocyte reaction. The partially purified activity significantly
       inhibited the adoptive transfer of diabetes. Our work provides evidence
       in support of the existence of T helper type 1, CD4+ T cells reactive to
       beta islet cell autoantigens that have acquired a protective instead of
       a diabetogenic effector function. These T cells mediate their protective
       action in part by production of an immunoregulatory activity capable of
       down-regulating immune responses, and they are likely to represent a
       population of regulatory T cells that normally plays a role in
       maintaining peripheral tolerance.
 DE    Amino Acid Sequence  Animal  Autoantigens/CHEMISTRY/IMMUNOLOGY
       Autoimmune Diseases/*IMMUNOLOGY  Base Sequence  Diabetes Mellitus,
       Insulin-Dependent/*IMMUNOLOGY  Female  Gene Rearrangement, T-Lymphocyte
       Immune Tolerance  Immunotherapy, Adoptive  Islets of
       Langerhans/*IMMUNOLOGY  Lymphocyte Culture Test, Mixed  Lymphocyte
       Transformation  Male  Mice  Mice, Inbred BALB C  Mice, Inbred NOD
       Molecular Sequence Data  Peptide Fragments/IMMUNOLOGY  Radiation Chimera
       Receptors, Antigen, T-Cell, alpha-beta/GENETICS  Spleen/IMMUNOLOGY
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Th1
       Cells/*IMMUNOLOGY  Th2 Cells/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).