Document 1164
 DOCN  M9591164
 TI    [Transformation of multiple basaliomas to squamous cell carcinomas in an
       HIV patient with Gorlin-Goltz syndrome]
 DT    9509
 AU    Wolfer LU; Blume-Peytavi U; Almond-Roesler B; Gollnick H; Orfanos CE;
       Universitats-Hautklinik und Poliklinik, Klinikum Steglitz,; Freien
       Universitat Berlin.
 SO    Hautarzt. 1995 Apr;46(4):268-71. Unique Identifier : AIDSLINE
       MED/95310144
 AB    We report on a 32-year-old male patient with Gorlin-Goltz syndrome, who
       presented with excessive numbers of superinfected basal cell carcinoma.
       This led us to suspect an underlying HIV infection, which was confirmed
       by ELISA and Western blotting. Laboratory investigation of the
       immunological state revealed severe immunosuppression with 267 CD4+
       lymphocytes and a CD4/CD8 ratio of 0.3. The histological picture showed
       multiple basal cell carcinomas, some of them transforming into squamous
       cell carcinomas. We suspect that the excessive number and the unusual
       clinical and histological picture of the basal cell carcinomas in this
       patient were probably influenced by the underlying HIV infection.
 DE    Adult  AIDS-Related Opportunistic Infections/PATHOLOGY  Basal Cell Nevus
       Syndrome/*PATHOLOGY  Biopsy  Carcinoma, Squamous Cell/*PATHOLOGY  Case
       Report  Cell Transformation, Neoplastic/*PATHOLOGY  English Abstract
       Human  HIV Seropositivity/*PATHOLOGY  Male  Skin/PATHOLOGY  Skin
       Neoplasms/*PATHOLOGY  Superinfection/PATHOLOGY  JOURNAL ARTICLE

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