Document 1166
 DOCN  M9591166
 TI    Secondary syphilis: a clinicopathologic study.
 DT    9509
 AU    Pandhi RK; Singh N; Ramam M; Department of Dermato-Venereology, All
       India Institute of Medical; Sciences, New Delhi.
 SO    Int J Dermatol. 1995 Apr;34(4):240-3. Unique Identifier : AIDSLINE
       MED/95310082
 AB    BACKGROUND. With the resurgence of syphilis in the HIV era, a greater
       awareness of the clinicopathologic features of the disease is desirable.
       This report describes and correlates the clinical and histopathologic
       features of secondary syphilis seen at a teaching hospital in Delhi,
       India. METHODS. Forty biopsies of mucocutaneous lesions from 31
       consecutive patients with secondary syphilis, seen between September
       1987 and January 1991, were studied and the histopathologic findings
       correlated with the clinical findings. RESULTS. A spectrum of
       histopathologic changes ranging from a minimal infiltrate to
       granulomatous inflammation throughout the dermis was seen. The pattern
       of inflammation correlated well with the type of skin lesion, with
       macules showing the least and nodules the most prominent changes. The
       predominant cell type in the infiltrate was the mononuclear
       cell/lymphocyte. Plasma cells were seen infrequently except in
       condylomata lata. Endothelial proliferation, the classical feature of
       the histopathology of syphilis was noted infrequently. CONCLUSIONS. The
       histologic manifestations of secondary syphilis appear to be as varied
       as the clinical ones. This calls for close interaction between the
       clinician and the pathologist to correlate the clinical, serologic, and
       histologic findings to establish the diagnosis of syphilis.
 DE    Adolescence  Adult  Aged  Child  Epithelium/PATHOLOGY  Female
       Granuloma/PATHOLOGY  Hair/PATHOLOGY  Human  India  Inflammation
       Keratosis/PATHOLOGY  Leukocytes, Mononuclear/PATHOLOGY  Lichenoid
       Eruptions/PATHOLOGY  Lymphocytes/PATHOLOGY  Male  Middle Age  Plasma
       Cells/PATHOLOGY  Psoriasis/PATHOLOGY  Skin/PATHOLOGY  Sweat
       Glands/PATHOLOGY  Syphilis, Cutaneous/*PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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