Document 1175
 DOCN  M9591175
 TI    Characterization of intermediate T-cell receptor cells expanding in the
       liver, thymus and other organs in autoimmune lpr mice: parallel analysis
       with their normal counterparts.
 DT    9509
 AU    Iiai T; Kimura M; Kawachi Y; Hirokawa K; Watanabe H; Hatakeyama K; Abo
       T; Department of Immunology, Niigata University School of Medicine,;
       Japan.
 SO    Immunology. 1995 Apr;84(4):601-8. Unique Identifier : AIDSLINE
       MED/95309971
 AB    Autoimmune MRL-lpr/lpr (lpr) mice were previously demonstrated to have
       an abnormal proliferation of intermediate T-cell receptor (TCR) cells of
       extrathymic origin in the liver. Despite this situation, thymectomy in
       lpr mice resulted in amelioration of autoimmune disease. To understand
       the underlying mechanism, we investigated associated T-cell
       differentiation in the thymus and other organs of these mice. When the
       disease was evoked, T cells with extrathymic properties, i.e.
       intermediate TCR-alpha beta cells expressing double-negative (DN) CD4-8-
       phenotype and interleukin-2 (IL-2) receptor beta-chain, became prominent
       not only in the liver, but also in the thymus. Such thymic T cells
       mainly resided in the medulla. A small-scale localization of such T
       cells was seen in the thymic medulla even in normal control mice. There
       was a heterogeneity among intermediate TCR cells in terms of the
       composition of DN cells and the expression of CD2 and B220 antigens,
       depending on the organs and the sites in the same organ. Intermediate
       TCR cells in the liver, thymus and autoimmune target organs (e.g.
       kidney) contained a high proportion of the active form (CD2+B220-),
       while intermediate TCR cells accumulating in peripheral organs, the
       spleen and lymph nodes, were mainly of the inactive form (CD2-B220+).
       The active form had an ability to proliferate in response to IL-2 and
       SEB, whereas the inactive form did not. The present results suggest that
       the proliferation of intermediate TCR cells occur at multiple sites;
       this may explain the effect of thymectomy, namely, the retarded onset of
       disease, in lpr mice.
 DE    Animal  Antigens, CD3/ANALYSIS  Autoimmune Diseases/*IMMUNOLOGY  Cell
       Division/IMMUNOLOGY  CD4-Positive T-Lymphocytes/IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Kidney/IMMUNOLOGY  Liver/*IMMUNOLOGY  Lupus
       Erythematosus, Systemic/*IMMUNOLOGY  Lymphocyte Subsets/IMMUNOLOGY  Mice
       Mice, Inbred Strains  Mice, Nude  Receptors, Antigen, T-Cell,
       alpha-beta/*ANALYSIS  Receptors, Interleukin-2/ANALYSIS
       Spleen/IMMUNOLOGY  Support, Non-U.S. Gov't  Thymus Gland/*IMMUNOLOGY
       JOURNAL ARTICLE

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