Document 1184
 DOCN  M9591184
 TI    Chronic effects of azidothymidine and acyclovir on pregnant rats.
 DT    9509
 AU    Mamede JA; Simoes M de J; Novo NF; Juliano Y; Oliveira-Filho RM; Kulay
       Junior L; Department of Gynecology and Obstetrics, Escola Paulista de;
       Medicina, Sao Paulo, Brazil.
 SO    Gen Pharmacol. 1995 May;26(3):523-6. Unique Identifier : AIDSLINE
       MED/95309634
 AB    1. The antiviral effect of azidothymidine (AZT) can be potentiated by
       acyclovir (ACV), and this drug association has been used in the
       management of HIV-infected patients. In the present study we examined
       the effects of such an association on rat pregnancy. 2. AZT (60 mg/kg
       b.w.) and ACV (60 mg/kg b.w.) were given to groups of pregnant rats once
       a day from the 1st to the 20th day of gestation. 3. Maternal body weight
       gain was severely affected by ACV; this effect was attenuated in rats
       treated with AZT+ACV and was virtually absent with AZT alone. 4. The
       abortive action of ACV was markedly diminished in the group treated with
       the association AZT+ACV. 5. The deleterious effects of ACV on rat
       pregnancy are presumably due to its extraplacental actions, and these
       are, at least in part, counteracted by concomitant treatment with AZT.
 DE    Acyclovir/*TOXICITY  Animal  Body Weight/DRUG EFFECTS  Drug Interactions
       Female  Fetal Resorption/CHEMICALLY INDUCED  Fetus/DRUG EFFECTS  Organ
       Weight/DRUG EFFECTS  Ovum Implantation/DRUG EFFECTS  Placenta/DRUG
       EFFECTS  Pregnancy  Pregnancy, Animal/*DRUG EFFECTS  Rats  Rats, Wistar
       Zidovudine/*TOXICITY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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