Document 1186
 DOCN  M9591186
 TI    Immunochemical and flow cytometric analysis of androgen receptor
       expression in thymocytes.
 DT    9509
 AU    Viselli SM; Olsen NJ; Shults K; Steizer G; Kovacs WJ; Division of
       Endocrinology, Vanderbilt University School of; Medicine, Nashville, TN
       32732-2250, USA.
 SO    Mol Cell Endocrinol. 1995 Mar;109(1):19-26. Unique Identifier : AIDSLINE
       MED/95309509
 AB    A variety of evidence suggests that the cells of the immune system are
       targets for the actions of gonadal steroids. Experiments in both normal
       animals and in autoimmune disease models have established that androgens
       exert immunomodulatory effects at the level of the thymus. We have
       attempted to define precisely the potential target cells for androgen
       action in the thymus using recently developed antibodies to the androgen
       receptor. We report here that these antibodies reveal AR expression in
       all classes of thymocytes defined by surface markers CD4 and CD8. The
       highest levels of AR expression were observed in the CD4-CD8+ and
       CD4-CD8- subsets that include the most immature cells. These experiments
       establish that thymocytes are potential targets for direct actions of
       androgens. The data further suggest AR expression in thymocytes may be
       developmentally regulated in these cells, and that androgen effects
       early in the process of thymocyte selection may contribute to the sexual
       dimorphism of immune responsiveness.
 DE    Androgens/PHARMACOLOGY  Animal  CD4-Positive T-Lymphocytes/CHEMISTRY
       CD8-Positive T-Lymphocytes/CHEMISTRY  CHO Cells  *Flow Cytometry
       Hamsters  *Immunohistochemistry  Male  Mice  Mice, Inbred C57BL
       Receptors, Androgen/*ANALYSIS  Sex Characteristics  Support, Non-U.S.
       Gov't  Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes/*CHEMISTRY/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).