Document 1193
 DOCN  M9591193
 TI    Localization of infection in HIV antibody positive patients with fever.
       Comparison of the efficacy of Ga-67 citrate and radiolabeled human IgG.
 DT    9509
 AU    Buscombe JR; Oyen WJ; Corstens FH; Ell PJ; Miller RF; Institute of
       Nuclear Medicine, University College London Medical; School, United
       Kingdom.
 SO    Clin Nucl Med. 1995 Apr;20(4):334-9. Unique Identifier : AIDSLINE
       MED/95308834
 AB    Patients who are human immunodeficiency virus (HIV) antibody positive
       are at increased risk of life threatening infection. Scintigraphic
       imaging with Ga-67 citrate has been used to identify the presence and
       site of focal infection. However, focal accumulation of Ga-67 is not
       specific for infection. A retrospective study was performed to compare
       the accuracy of Ga-67 citrate and pooled human polyclonal immunoglobulin
       G (HIG) labeled with Tc-99m HIG and In-111 HIG in identifying infection
       in HIV antibody positive patients. Twenty-five studies were performed
       using Ga-67 and Tc-99m HIG were compared with a second group of 25
       studies using In-111 HIG in HIV antibody positive patients presenting
       with fever, but without localizing symptoms or signs. In-111 HIG
       identified 20 of 22 sites of infection and also accumulated in 5 sites
       without infection (accuracy = 90%). This was significantly more accurate
       (X2, P < 0.05) than Ga-67 which identified 19 of 20 sites of infection,
       but accumulated in 18 sites without infection (accuracy = 74%) and
       Tc-99m HIG which identified infection in 11 of 20 sites, but accumulated
       in 8 sites without infection (accuracy = 77%). There was no significant
       difference between the accuracy of Ga-67 and Tc-99m HIG. From this
       preliminary study In-111 HIG would seem to be the best agent for
       identifying infection in HIV antibody positive patients with fever.
 DE    Adolescence  Adult  AIDS-Related Opportunistic Infections/*RADIONUCLIDE
       IMAGING  Citrates/*DIAGNOSTIC USE  Comparative Study
       Fever/*COMPLICATIONS  Focal Infection/RADIONUCLIDE IMAGING  Gallium
       Radioisotopes/*DIAGNOSTIC USE  Human  HIV Seropositivity/*COMPLICATIONS
       Immunoglobulins/DIAGNOSTIC USE  Indium Radioisotopes/DIAGNOSTIC USE
       Male  Middle Age  Retrospective Studies  Sensitivity and Specificity
       Technetium/DIAGNOSTIC USE  JOURNAL ARTICLE

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