Document 1198
 DOCN  M9591198
 TI    [Premature labor in HIV infected women. Swiss HIV and Pregnancy Study
       Group]
 DT    9509
 AU    Zurrer M; Biedermann K; Rudin C; Lauper U; Klinik und Poliklinik fur
       Geburtshilfe, Universitatsspital; Zurich.
 SO    Z Geburtshilfe Neonatol. 1995 Mar-Apr;199(2):58-64. Unique Identifier :
       AIDSLINE MED/95308382
 AB    In the Swiss Study HIV and pregnancy we observed 153 singleton
       pregnancies of HIV-positive women. 23 (15%) of those ended with a
       premature delivery. For drug addicts (n = 100), the incidence of
       prematurity, 20%, significantly higher than in those free of drugs (n =
       53) with 5.6%. The most frequent cause of prematurity was premature
       labor or rupture of the membranes (n = 13), followed by maternal illness
       (n = 8) and fetal complications (n = 2). Women with premature delivery
       tended to have lower CD4 cell counts than those with term delivery
       (29.4% vs 12.0% with < 200 CD4 cells/microliters). Low CD4 cell counts
       and drug consumption are two independent but cumulative risks for severe
       infections. 16 of the 153 women (12 with, 4 without drug consumption)
       had severe infections during pregnancy; in 4 cases (25%), this led to
       prematurity. The most common infection was pneumonia (14/16), further
       one case of pyelonephritis and one of cerebral toxoplasmosis. Two of
       these 16 infants (12.5%) were HIV-positive. We could not confirm a
       relationship between prematurity and vertical HIV transmission. Of the
       HIV-classified children, 3/18 (16.7%) premature infants and 16/74
       (21.6%) term infants were infected.
 DE    Adult  AIDS-Related Opportunistic Infections/EPIDEMIOLOGY/IMMUNOLOGY
       Cross-Sectional Studies  CD4 Lymphocyte Count  Disease Transmission,
       Vertical  English Abstract  Extraction, Obstetrical  Female  Human  HIV
       Infections/*EPIDEMIOLOGY/IMMUNOLOGY/TRANSMISSION  Incidence  Infant,
       Newborn  Labor, Premature/*EPIDEMIOLOGY/IMMUNOLOGY  Male  Pilot Projects
       Pregnancy  Pregnancy Complications, Infectious/*EPIDEMIOLOGY/IMMUNOLOGY
       *Pregnancy, High-Risk  Substance Abuse,
       Intravenous/EPIDEMIOLOGY/IMMUNOLOGY  Switzerland/EPIDEMIOLOGY  JOURNAL
       ARTICLE

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